Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0037 | 0.0109 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.0201 | 0.2179 | 0.8689 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0201 | 0.2179 | 0.7472 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0227 | 0.2503 | 0.8561 |
Loa Loa (eye worm) | plexin A | 0.0043 | 0.0193 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2581 | 0.8842 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0032 | 0.0058 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0032 | 0.0058 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.0259 | 0.2905 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0259 | 0.2905 | 1 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0201 | 0.2179 | 0.7472 |
Schistosoma mansoni | protein kinase | 0.0227 | 0.2503 | 1 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0259 | 0.2905 | 0.2882 |
Echinococcus multilocularis | activin receptor type | 0.0227 | 0.2503 | 0.2478 |
Schistosoma mansoni | plexin | 0.0037 | 0.0109 | 0.0309 |
Loa Loa (eye worm) | TK protein kinase | 0.0259 | 0.2905 | 1 |
Echinococcus multilocularis | plexin a4 | 0.0043 | 0.0193 | 0.0161 |
Brugia malayi | plexin A | 0.0043 | 0.0193 | 0.0301 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0201 | 0.2179 | 0.2153 |
Echinococcus granulosus | activin receptor type | 0.0227 | 0.2503 | 0.8599 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0227 | 0.2503 | 0.8561 |
Echinococcus granulosus | plexin a4 | 0.0043 | 0.0193 | 0.0558 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.