Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aurora kinase A | 0.0258 | 0.5898 | 0.3432 |
Entamoeba histolytica | protein kinase, putative | 0.0258 | 0.5898 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0258 | 0.5898 | 1 |
Brugia malayi | serine/threonine kinase 12 | 0.0258 | 0.5898 | 0.3432 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0258 | 0.5898 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0258 | 0.5898 | 0.5898 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0258 | 0.5898 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0258 | 0.5898 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0258 | 0.5898 | 0.3432 |
Trichomonas vaginalis | AGC family protein kinase | 0.0258 | 0.5898 | 0.5898 |
Entamoeba histolytica | protein kinase, putative | 0.0258 | 0.5898 | 1 |
Entamoeba histolytica | protein kinase , putative | 0.0258 | 0.5898 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0258 | 0.5898 | 0.3432 |
Trichomonas vaginalis | AGC family protein kinase | 0.0258 | 0.5898 | 0.5898 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0258 | 0.5898 | 0.3432 |
Echinococcus granulosus | aurora kinase A | 0.0258 | 0.5898 | 0.3432 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0258 | 0.5898 | 0.3432 |
Loa Loa (eye worm) | AUR protein kinase | 0.0258 | 0.5898 | 0.3432 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0258 | 0.5898 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0258 | 0.5898 | 0.5898 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.5898 | 0.3432 |
Giardia lamblia | Aurora kinase | 0.0258 | 0.5898 | 0.3432 |
Leishmania major | protein kinase, putative | 0.0258 | 0.5898 | 0.3432 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0258 | 0.5898 | 0.3432 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0258 | 0.5898 | 0.3432 |
Toxoplasma gondii | aurora kinase | 0.0258 | 0.5898 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0258 | 0.5898 | 0.3432 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0258 | 0.5898 | 1 |
Trypanosoma brucei | aurora B kinase | 0.0258 | 0.5898 | 0.3432 |
Loa Loa (eye worm) | AUR protein kinase | 0.0258 | 0.5898 | 0.3432 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0216 | 0.3754 | 0.3754 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior substrate addition measured after 50 mins by streptavidin-coated scintillation proximity assay | ChEMBL. | 22148754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.