Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bradykinin receptor B1 | Starlite/ChEMBL | References |
Homo sapiens | bradykinin receptor B2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bradykinin receptor B2 | 391 aa | 354 aa | 19.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | SWI:SNF matrix associated | 0.0334 | 0.057 | 0.0865 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0334 | 0.057 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.1287 | 0.3098 | 0.3098 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1297 | 0.3123 | 0.3123 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.1297 | 0.3123 | 0.4741 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1297 | 0.3123 | 0.3123 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2603 | 0.6588 | 0.6381 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1297 | 0.3123 | 0.3123 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.1297 | 0.3123 | 0.4741 |
Trichomonas vaginalis | CAMK family protein kinase | 0.2603 | 0.6588 | 0.6381 |
Echinococcus granulosus | Upstream activation factor subunit UAF30 | 0.0334 | 0.057 | 0.0865 |
Echinococcus multilocularis | tumor protein p63 | 0.0335 | 0.0573 | 0.087 |
Brugia malayi | brahma associated protein 60 kDa | 0.0334 | 0.057 | 0.057 |
Echinococcus granulosus | tumor protein p63 | 0.0335 | 0.0573 | 0.087 |
Toxoplasma gondii | SWIB/MDM2 domain-containing protein | 0.0334 | 0.057 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.057 | 0.057 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.2603 | 0.6588 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.057 | 0.057 |
Loa Loa (eye worm) | brahma associated protein | 0.0334 | 0.057 | 0.057 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0334 | 0.057 | 0.0865 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.057 | 0.057 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.2603 | 0.6588 | 1 |
Onchocerca volvulus | 0.0334 | 0.057 | 1 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0334 | 0.057 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.1287 | 0.3098 | 0.4702 |
Brugia malayi | brahma associated protein 60 kDa | 0.0334 | 0.057 | 0.057 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1297 | 0.3123 | 0.3123 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1297 | 0.3123 | 0.4741 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0334 | 0.057 | 1 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0334 | 0.057 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.1287 | 0.3098 | 0.3098 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0334 | 0.057 | 0.0865 |
Echinococcus granulosus | calcium activated potassium channel | 0.1297 | 0.3123 | 0.4741 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0334 | 0.057 | 1 |
Plasmodium falciparum | SWIB/MDM2 domain-containing protein | 0.0334 | 0.057 | 1 |
Plasmodium vivax | SWIB/MDM2 domain-containing protein, putative | 0.0334 | 0.057 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1287 | 0.3098 | 0.3098 |
Schistosoma mansoni | brg-1 associated factor | 0.0334 | 0.057 | 0.057 |
Echinococcus multilocularis | calcium activated potassium channel | 0.1297 | 0.3123 | 0.4741 |
Chlamydia trachomatis | SWIB complex protein | 0.0334 | 0.057 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1297 | 0.3123 | 0.4741 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0334 | 0.057 | 0.057 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0334 | 0.057 | 0.0865 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1297 | 0.3123 | 0.3123 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0334 | 0.057 | 0.5 |
Brugia malayi | Kinase associated domain 1 family protein | 0.1287 | 0.3098 | 0.3098 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 9.1 | Antagonist activity at human bradykinin B2 receptor expressed in dhfr-deficient CHO cells assessed as inhibition of bradykinin-induced inositol monophosphate accumulation preincubated for 15 mins prior bradykinin induction measured after 40 mins by liquid scintillation spectrometry | ChEMBL. | 22342268 |
Ki (binding) | > 5 | Displacement of [3H][desArg9]Lys-Bradykinin from human bradykinin B1 receptor expressed in CHO cells | ChEMBL. | 22342268 |
Ki (binding) | = 10.2 | Displacement of [3H]-Bradykinin from human bradykinin B2 receptor expressed in CHO cells membrane after 60 mins by scintillation counting | ChEMBL. | 22342268 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.