Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.3504 | 0.3044 | 0.3044 |
Schistosoma mansoni | hypothetical protein | 0.3478 | 0.3018 | 0.3018 |
Echinococcus multilocularis | hypothetical protein | 0.3478 | 0.3018 | 0.4609 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3504 | 0.3044 | 0.3044 |
Brugia malayi | Kinase associated domain 1 family protein | 0.3478 | 0.3018 | 0.3014 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.3504 | 0.3044 | 0.4649 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.1023 | 0.0582 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 0.0459 | 0.0459 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.3504 | 0.3044 | 0.4649 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.7034 | 0.6548 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3504 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.1023 | 0.0582 | 0.0582 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.7034 | 0.6548 | 1 |
Echinococcus granulosus | calcium activated potassium channel | 0.3504 | 0.3044 | 0.4649 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3504 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.3478 | 0.3018 | 0.3018 |
Echinococcus multilocularis | calcium activated potassium channel | 0.3504 | 0.3044 | 0.4649 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.3504 | 0.3044 | 0.4649 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.1023 | 0.0582 | 0.0582 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.3504 | 0.3044 | 0.4649 |
Schistosoma mansoni | hypothetical protein | 0.3478 | 0.3018 | 0.3018 |
Chlamydia trachomatis | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase | 0.0871 | 0.0431 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3504 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.1023 | 0.0582 | 0.0582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 4 ug ml-1 | Antibacterial activity against Escherichia coli after 16 to 20 hrs by broth microdilution method | ChEMBL. | 22175825 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.