Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.5494 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0178 | 0.2179 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0185 | 0.2338 | 0.4255 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0178 | 0.2179 | 0.5 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0401 | 0.7672 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0401 | 0.7672 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0121 | 0.0767 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0096 | 0.0175 |
Schistosoma mansoni | ryanodine receptor related | 0.0495 | 1 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0151 | 0.1508 | 0.0785 |
Loa Loa (eye worm) | ryanodine receptor | 0.0117 | 0.0655 | 0.1193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 ug ml-1 | Inhibitory activity against E. coli DNA gyrase | ChEMBL. | 15125947 |
IC50 (binding) | = 16 ug ml-1 | Inhibitory activity against E. coli DNA gyrase | ChEMBL. | 15125947 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against Staphylococcus aureus FDA 209P | ChEMBL. | 15125947 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against Staphylococcus aureus KMP9 | ChEMBL. | 15125947 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against Enterococcus faecalis ATCC 29212 | ChEMBL. | 15125947 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity against Enterococcus faecalis KU 1777 | ChEMBL. | 15125947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.