Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative | 0.0193 | 0.0808 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0193 | 0.0808 | 0.1748 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0273 | 0.1922 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0427 | 0.4063 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0264 | 0.1804 | 0.1706 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0273 | 0.1922 | 0.4572 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0273 | 0.1922 | 0.4572 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.031 | 0.0487 |
Entamoeba histolytica | protein kinase, putative | 0.0427 | 0.4063 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0408 | 0.38 | 0.9333 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0427 | 0.4063 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Giardia lamblia | Kinase, AGC PKA | 0.0273 | 0.1922 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0273 | 0.1922 | 0.1825 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Schistosoma mansoni | protein kinase | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0408 | 0.38 | 0.9333 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.031 | 0.0487 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0193 | 0.0808 | 0.1748 |
Entamoeba histolytica | protein kinase, putative | 0.0193 | 0.0808 | 0.1748 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0193 | 0.0808 | 0.1748 |
Toxoplasma gondii | AGC kinase | 0.0408 | 0.38 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.031 | 0.0194 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0273 | 0.1922 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0264 | 0.1804 | 0.4273 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0427 | 0.4063 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.031 | 0.0487 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0427 | 0.4063 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0273 | 0.1922 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0264 | 0.1804 | 0.1706 |
Brugia malayi | Protein kinase domain containing protein | 0.0408 | 0.38 | 0.9333 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0427 | 0.4063 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.0273 | 0.1922 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1087 | 0.2457 |
Brugia malayi | Protein kinase domain containing protein | 0.0427 | 0.4063 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Entamoeba histolytica | protein kinase, putative | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0427 | 0.4063 | 0.3992 |
Entamoeba histolytica | protein kinase 2, putative | 0.0273 | 0.1922 | 0.4572 |
Echinococcus granulosus | nervana 2 | 0.0264 | 0.1804 | 0.4273 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0273 | 0.1922 | 0.4572 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.031 | 0.0487 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | aurora kinase A | 0.0193 | 0.0808 | 0.0698 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Echinococcus granulosus | nervana 2 | 0.0264 | 0.1804 | 0.4273 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0273 | 0.1922 | 0.4572 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0193 | 0.0808 | 0.1748 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0193 | 0.0808 | 0.1748 |
Brugia malayi | serine/threonine kinase 12 | 0.0193 | 0.0808 | 0.1748 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0213 | 0.1087 | 0.0981 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0273 | 0.1922 | 0.4572 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0193 | 0.0808 | 0.1748 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0264 | 0.1804 | 0.4273 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0193 | 0.0808 | 0.1748 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0273 | 0.1922 | 0.4572 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0273 | 0.1922 | 0.1825 |
Echinococcus granulosus | hormone sensitive lipase | 0.0213 | 0.1087 | 0.2457 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0264 | 0.1804 | 0.1706 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0273 | 0.1922 | 0.4572 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.031 | 0.0194 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0193 | 0.0808 | 0.0698 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Entamoeba histolytica | protein kinase , putative | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | nervana 2 | 0.0264 | 0.1804 | 0.1706 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Echinococcus granulosus | aurora kinase A | 0.0193 | 0.0808 | 0.1748 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0273 | 0.1922 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0408 | 0.38 | 0.9333 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0408 | 0.38 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiproliferative activity against human MCF7 cells after 3 days by MTT assay | ChEMBL. | 22361137 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human HeLa cells after 3 days by MTT assay | ChEMBL. | 22361137 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human Bel7402 cells after 3 days by MTT assay | ChEMBL. | 22361137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.