TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.33 | Formula: C18H25Cl2N5O
H donors: 4 H acceptors: 3 LogP: 4.48 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@]1(CNc2nc(N)nc(c2N)Cl)CC(C1)CCc1ccccc1.Cl
InChi: 1S/C18H24ClN5O.ClH/c19-15-14(20)16(24-17(21)23-15)22-10-18(11-25)8-13(9-18)7-6-12-4-2-1-3-5-12;/h1-5,13,25H,6-11,20H2,(H3,21,22,23,24);1H/t13?,18-;
InChiKey: VIAPFHALGCEHPL-AEWGNMMUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0121	0.0052	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0338	0.0587	0.0879
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0131	0.0076	0.0076
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0131	0.0076	0.0078
Trichomonas vaginalis	CMGC family protein kinase	0.2495	0.5894	1
Loa Loa (eye worm)	TK protein kinase	0.0121	0.0052	0.0054
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.2495	0.5894	1
Echinococcus multilocularis	tissue type plasminogen activator	0.0179	0.0195	0.0195
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0131	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0195	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0076	0.0078
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0469	0.0908	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0076	0.0078
Loa Loa (eye worm)	TK/ROR protein kinase	0.0191	0.0225	0.0233
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0132	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0469	0.0908	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0232	0.0326	0.0337
Mycobacterium ulcerans	putative regulatory protein	0.0338	0.0587	0.5
Toxoplasma gondii	hypothetical protein	0.0338	0.0587	0.0879
Plasmodium falciparum	cysteine repeat modular protein 1	0.0179	0.0195	0.2329
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0131	0.0076	0.0076
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0469	0.0908	0.1431
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0132	0.0079	0.0079
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0338	0.0587	0.5
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	tissue type plasminogen activator	0.0179	0.0195	0.0195
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0132	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0338	0.0587	0.0879
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.2495	0.5894	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0469	0.0908	0.1431
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0131	0.0076	0.0076
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0131	0.0076	0.0076
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0121	0.0052	0.0052
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Schistosoma mansoni	tyrosine kinase	0.0514	0.1019	0.162
Trichomonas vaginalis	conserved hypothetical protein	0.0338	0.0587	0.0879
Loa Loa (eye worm)	hypothetical protein	0.3694	0.8846	0.914
Echinococcus multilocularis	mitogen activated protein kinase 3	0.2495	0.5894	0.5894
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0121	0.0052	0.0052
Brugia malayi	Trypsin family protein	0.0232	0.0326	0.0275
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0132	0.0079	0.0079
Brugia malayi	Protein kinase domain containing protein	0.0191	0.0225	0.0174
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0131	0.0076	0.0076
Toxoplasma gondii	hypothetical protein	0.0338	0.0587	0.0879
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Schistosoma mansoni	tyrosine kinase	0.0132	0.0079	0.0006
Brugia malayi	SRC-1	0.0132	0.0079	0.0027
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0155	0.0135	0.0135
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0121	0.0052	0.0052
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	conserved hypothetical protein	0.0338	0.0587	0.0879
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0132	0.0079	0.0079
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0131	0.0076	0.0024
Toxoplasma gondii	GAF domain-containing protein	0.0338	0.0587	0.0879
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0131	0.0076	0.0076
Echinococcus multilocularis	protein tyrosine kinase	0.0514	0.1019	0.1019
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2495	0.5894	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0232	0.0326	0.043
Mycobacterium ulcerans	putative regulatory protein	0.0338	0.0587	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Schistosoma mansoni	tyrosine kinase	0.0132	0.0079	0.0006
Brugia malayi	Protein kinase domain containing protein	0.052	0.1033	0.0986
Trichomonas vaginalis	CMGC family protein kinase	0.2495	0.5894	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.2495	0.5894	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0132	0.0079	0.0079
Echinococcus multilocularis	mitogen activated protein kinase	0.2495	0.5894	0.5894
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.2495	0.5894	0.6089
Toxoplasma gondii	kringle domain-containing protein	0.0179	0.0195	0.0205
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0132	0.0079	0.0079
Echinococcus granulosus	mitogen activated protein kinase	0.2495	0.5894	0.5894
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0232	0.0326	0.0337
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0338	0.0587	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0132	0.0079	0.0079
Mycobacterium leprae	conserved hypothetical protein	0.0338	0.0587	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0232	0.0326	0.043
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0131	0.0076	0.0024
Loa Loa (eye worm)	TK/FAK protein kinase	0.052	0.1033	0.1068
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0338	0.0587	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.2495	0.5894	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0131	0.0076	0.0024
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.2495	0.5894	1
Plasmodium falciparum	GAF domain-related protein, putative	0.0338	0.0587	1
Echinococcus granulosus	tyrosine kinase	0.0121	0.0052	0.0052
Trichomonas vaginalis	CMGC family protein kinase	0.2495	0.5894	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0109	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0131	0.0076	0.0078
Echinococcus granulosus	mitogen activated protein kinase 3	0.2495	0.5894	0.5894
Loa Loa (eye worm)	hypothetical protein	0.4033	0.9679	1
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0131	0.0076	0.0076
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0132	0.0079	0.0079
Brugia malayi	MAP kinase sur-1	0.2495	0.5894	0.5872
Trypanosoma cruzi	hypothetical protein, conserved	0.0179	0.0195	0.0205
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0469	0.0908	0.0908
Plasmodium vivax	hypothetical protein, conserved	0.0338	0.0587	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0131	0.0076	0.0076
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0131	0.0076	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.2495	0.5894	1
Loa Loa (eye worm)	SRC-1	0.0132	0.0079	0.0082
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0469	0.0908	0.0908
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0179	0.0195	0.2329
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0131	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0469	0.0908	0.0938
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0469	0.0908	0.1431
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.2495	0.5894	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Loa Loa (eye worm)	PDE1B protein	0.0131	0.0076	0.0078
Echinococcus granulosus	tyrosine protein kinase Blk	0.0121	0.0052	0.0052
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0131	0.0076	0.0076
Onchocerca volvulus		0.0232	0.0326	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0132	0.0079	0.0079
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0469	0.0908	0.086
Schistosoma mansoni	hypothetical protein	0.0179	0.0195	0.0205
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	CMGC family protein kinase	0.2495	0.5894	1
Giardia lamblia	Kinase, CMGC MAPK	0.2495	0.5894	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	protein tyrosine kinase	0.0514	0.1019	0.1019
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0109	0.0022	0.0022
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0132	0.0079	0.0079
Toxoplasma gondii	hypothetical protein	0.0338	0.0587	0.0879
Brugia malayi	Kringle domain containing protein	0.0179	0.0195	0.0143
Leishmania major	hypothetical protein, conserved	0.0179	0.0195	0.0205
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0469	0.0908	0.1431
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.2495	0.5894	1
Trypanosoma brucei	protein kinase, putative	0.2495	0.5894	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0469	0.0908	0.1431
Onchocerca volvulus		0.0182	0.0202	0.0568
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0469	0.0908	0.1431
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0469	0.0908	0.1431
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0131	0.0076	0.0076

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-6.096	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.429	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.389	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.978	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.932	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.924	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.788	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.768	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.745	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.716	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.644	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.574	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.573	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.525	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.463	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.453	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.315	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.292	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.254	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.087	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.068	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1966259

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1621206