Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Echinococcus granulosus | Cystatin B Stefin B | 0.0013 | 0.5 | 0.5 |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | cystatin | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | cystatin | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0013 | 0.5 | 0.5 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | cystatin B | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0013 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.788 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.777 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.73 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.284 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.049 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.952 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.788 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.763 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.728 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.671 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.663 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.