Detailed view for TVAG_272260

Basic information

TDR Targets ID: 891849
Trichomonas vaginalis, Clan IH, family I25, phytocystatin-like peptidase inhibitor
Source Database / ID: 

pI: 6.8757 | Length (AA): 91 | MW (Da): 9814 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00031   Cystatin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004869   cysteine protease inhibitor activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_149594)

Species Accession Gene Product
Arabidopsis thaliana AT5G47550   cysteine proteinase inhibitor 5
Arabidopsis thaliana AT4G16500   cysteine proteinase inhibitor 4
Oryza sativa 4327535   Os01g0803200
Oryza sativa 4332021   Os03g0210200
Oryza sativa 4333170   Os03g0429000
Oryza sativa 4339190   Os05g0494200
Trichomonas vaginalis TVAG_127040   Clan IH, family I25, phytocystatin-like peptidase inhibitor
Trichomonas vaginalis TVAG_034880   Clan IH, family I25, phytocystatin-like peptidase inhibitor
Trichomonas vaginalis TVAG_272260   Clan IH, family I25, phytocystatin-like peptidase inhibitor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0034 0.2847 0.7806
0.0013 0.5 0.5
0.0007 0.5 0.5
0.0082 1 0.5
0.0053 0.4568 1
0.0066 0.5 0.5
0.0047 0.5 0.5
0.0046 0.9262 1
0.0027 0.5 0.5
0.0093 0.2958 1
0.0053 0.4543 1
0.0041 0.5 0.5
0.0046 0.5 0.5
0.0039 0.5 0.5
0.0066 1 0.5
0.0053 0.5 0.5
0.0046 0.5 0.5
0.0034 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TVAG_272260 (Trichomonas vaginalis), Clan IH, family I25, phytocystatin-like peptidase inhibitor
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