Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Trypanosoma cruzi | prolyl endopeptidase | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 697 aa | 703 aa | 23.9 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0126 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0316 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0316 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0126 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0316 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0283 | 0.8259 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0316 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0316 | 1 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0316 | 1 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.45 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 0.45 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 19 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Ki (binding) | = 19 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 41336 | ||
Annotator: | millerja@u.washington.edu | Comment: | Compounds 1-4 in referenced paper. | References: | 15581422 |
1 literature reference was collected for this gene.