Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1128 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0771 | 0.6007 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0258 | 0.0256 | 0.0426 |
Trichomonas vaginalis | AGC family protein kinase | 0.0459 | 0.2507 | 0.3915 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1128 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0459 | 0.2507 | 0.3045 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0749 | 0.5751 | 0.9555 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0771 | 0.6007 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0459 | 0.2507 | 0.3915 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0356 | 0.1359 | 0.1918 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.041 | 0.0498 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0771 | 0.6007 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0771 | 0.6007 | 1 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0459 | 0.2507 | 0.3915 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0614 | 0.4242 | 0.6931 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0258 | 0.0256 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.053 | 0.33 | 0.5294 |
Loa Loa (eye worm) | hypothetical protein | 0.05 | 0.2962 | 0.3597 |
Trichomonas vaginalis | AGC family protein kinase | 0.0459 | 0.2507 | 0.3915 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.053 | 0.33 | 0.5294 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.05 | 0.2962 | 0.0607 |
Entamoeba histolytica | protein kinase, putative | 0.0459 | 0.2507 | 0.3915 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0342 | 0.1197 | 0.1637 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0372 | 0.1535 | 0.5 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.097 | 0.8235 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0614 | 0.4242 | 0.6931 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0459 | 0.2507 | 0.3045 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0771 | 0.6007 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.05 | 0.2962 | 0.4706 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0771 | 0.6007 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0459 | 0.2507 | 0.3915 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0459 | 0.2507 | 0.2311 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0771 | 0.6007 | 1 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.05 | 0.2962 | 0.0607 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 uM | Inhibition of wild type HIV-1 protease assessed as hydrolysis of fluorogenic substrate Abz-Thr-Ile-Nle-Phe(NO2)-Gln-Arg after 10 mins by fluorescence assay | ChEMBL. | 22414613 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.