Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1147 | 0.3107 | 0.0813 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1458 | 0.5336 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1458 | 0.5336 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1699 | 0.7067 | 0.7197 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0883 | 0.1213 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1947 | 0.8846 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1383 | 0.4802 | 0.5428 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1699 | 0.7067 | 0.7197 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1947 | 0.8846 | 0.8462 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.1699 | 0.7067 | 0.7197 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.1699 | 0.7067 | 0.7197 |
Echinococcus granulosus | bile acid beta glucosidase | 0.1699 | 0.7067 | 0.7197 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.1699 | 0.7067 | 0.7197 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.1947 | 0.8846 | 0.8462 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.2108 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.6198 | Inhibition concentration against human adenosine kinase | ChEMBL. | 11958989 |
IC50 (binding) | = 1.62 | Concentration required for 50% inhibition of the adenosine kinase (AK) activity. | ChEMBL. | 15149648 |
IC50 (binding) | = 4.11 | Binding affinity to ENT1 transporter (unknown origin) | ChEMBL. | 18289860 |
IC50 (binding) | = 0.024 uM | Inhibition of human adenosine kinase activity | ChEMBL. | 11958989 |
IC50 (binding) | = 0.024 uM | Inhibition of recombinant human adenosine kinase | ChEMBL. | 10956196 |
IC50 (binding) | = 0.024 uM | Inhibition of human adenosine kinase activity | ChEMBL. | 11958989 |
IC50 (binding) | = 0.024 uM | Inhibition of recombinant human adenosine kinase | ChEMBL. | 10956196 |
IC50 (functional) | = 13 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
Log IC50 (binding) | = 1.6198 | Inhibition concentration against human adenosine kinase | ChEMBL. | 11958989 |
Log IC50 (binding) | = 4.11 | Binding affinity to ENT1 transporter (unknown origin) | ChEMBL. | 18289860 |
log(10'3/IC50) (binding) | = 4.62 | Inhibition of adenosine kinase | ChEMBL. | 18359230 |
logIC50 (binding) | = -1.6198 | Inhibition of adenosine kinase (unknown origin) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 2846837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
5 literature references were collected for this gene.