Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | two component sensor histidine kinase DevS | 0.0451 | 0.3771 | 0.5 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0326 | 0.2081 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0326 | 0.2081 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0374 | 0.2733 | 0.6179 |
Echinococcus multilocularis | geminin | 0.0188 | 0.0206 | 0.0209 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0206 | 0.0206 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0499 | 0.4423 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0499 | 0.4423 | 1 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0911 | 1 | 1 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.0451 | 0.3771 | 1 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0326 | 0.2081 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 1 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0899 | 0.9851 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0499 | 0.4423 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0499 | 0.4423 | 1 |
Echinococcus granulosus | geminin | 0.0188 | 0.0206 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0188 | 0.0206 | 0.0206 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0326 | 0.2081 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0374 | 0.2733 | 0.6179 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.