Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | free fatty acid receptor 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Free fatty acid receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | neuropeptides capa receptor | Free fatty acid receptor 1 | 300 aa | 242 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0068 | 0.5 | 0.5 |
Toxoplasma gondii | oxidoreductase, 2OG-Fe(II) oxygenase family protein | 0.0068 | 0.5 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0068 | 0.5 | 0.5 |
Trypanosoma cruzi | 2OG-Fe(II) oxygenase superfamily, putative | 0.0068 | 0.5 | 0.5 |
Schistosoma mansoni | prolyl 4-hydroxylase alpha subunit 1 | 0.0068 | 0.5 | 0.5 |
Toxoplasma gondii | tetratricopeptide repeat-containing protein | 0.0068 | 0.5 | 0.5 |
Toxoplasma gondii | hypoxia- inducible factor prolyl hydroxylase (phd2), putative | 0.0068 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0068 | 0.5 | 0.5 |
Trypanosoma brucei | 2OG-Fe(II) oxygenase superfamily, putative | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0068 | 0.5 | 0.5 |
Loa Loa (eye worm) | prolyl 4-hydroxylase 2 | 0.0068 | 0.5 | 0.5 |
Echinococcus granulosus | prolyl 4 hydroxylase subunit alpha 1 | 0.0068 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0068 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.5 | 0.5 |
Echinococcus multilocularis | prolyl 4 hydroxylase subunit alpha 1 | 0.0068 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Efficacy (functional) | = 2 % | Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration at 1 uM after 90 secs by FLIPR assay in presence of 0.1% BSA relative to control | ChEMBL. | 22242551 |
Efficacy (functional) | = 101 % | Agonist activity at human GR40 receptor expressed in CHO cells assessed as increase in intracellular calcium concentration at 10 uM after 90 secs by FLIPR assay in presence of 0.1% BSA relative to control | ChEMBL. | 22242551 |
Ki (binding) | > 10 uM | Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA | ChEMBL. | 22242551 |
Ki (binding) | > 10 uM | Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from rat GPR40 receptor expressed in CHO cells after 90 mins by scintillation counting in presence of 0.2% BSA | ChEMBL. | 22242551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.