Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | squalene synthase, putative | 0.0313 | 0.0555 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.1485 | 0.6837 | 1 |
Mycobacterium tuberculosis | Probable phytoene synthase PhyA | 0.0428 | 0.1172 | 0.5 |
Trypanosoma cruzi | squalene synthase, putative | 0.0313 | 0.0555 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1485 | 0.6837 | 1 |
Mycobacterium ulcerans | phytoene synthase, CrtB | 0.0428 | 0.1172 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1596 | 0.743 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.2076 | 1 | 1 |
Leishmania major | squalene synthase, putative | 0.0313 | 0.0555 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.1965 | 0.9407 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1386 | 0.6307 | 0.9225 |
Trypanosoma brucei | squalene synthase, putative | 0.0313 | 0.0555 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.