Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0268 | 0.2889 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0268 | 0.2889 | 0.2889 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0276 | 0.3044 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0268 | 0.2889 | 0.9491 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | nuclear receptor NHR-88 | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0142 | 0.0309 | 0.0309 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0268 | 0.2889 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0142 | 0.0309 | 0.0521 |
Brugia malayi | steroid hormone receptor | 0.0417 | 0.5933 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0268 | 0.2889 | 0.4869 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | coup transcription factor | 0.0268 | 0.2889 | 0.2889 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0268 | 0.2889 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0268 | 0.2889 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0268 | 0.2889 | 0.2889 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0268 | 0.2889 | 0.2889 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Schistosoma mansoni | thyroid hormone receptor | 0.0268 | 0.2889 | 0.2889 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0268 | 0.2889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0142 | 0.0309 | 0.0309 |
Echinococcus granulosus | FTZ F1 alpha | 0.0268 | 0.2889 | 0.9491 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0268 | 0.2889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0268 | 0.2889 | 0.4869 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0142 | 0.0309 | 0.0521 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0268 | 0.2889 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0268 | 0.2889 | 0.2889 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0268 | 0.2889 | 0.9491 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0268 | 0.2889 | 0.9491 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0268 | 0.2889 | 0.4869 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0268 | 0.2889 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0142 | 0.0309 | 0.0521 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0142 | 0.0309 | 0.1016 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0142 | 0.0309 | 0.0521 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0268 | 0.2889 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0268 | 0.2889 | 0.9491 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0268 | 0.2889 | 0.9491 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0268 | 0.2889 | 0.2889 |
Onchocerca volvulus | 0.0268 | 0.2889 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0417 | 0.5933 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0268 | 0.2889 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0268 | 0.2889 | 0.9491 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0268 | 0.2889 | 0.2889 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0268 | 0.2889 | 0.2889 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0268 | 0.2889 | 0.4869 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0268 | 0.2889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0268 | 0.2889 | 0.9491 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0268 | 0.2889 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0268 | 0.2889 | 0.2889 |
Brugia malayi | ecdysteroid receptor | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0268 | 0.2889 | 0.9491 |
Schistosoma mansoni | nuclear hormone receptor | 0.0268 | 0.2889 | 0.2889 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0268 | 0.2889 | 0.2889 |
Brugia malayi | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0268 | 0.2889 | 0.4869 |
Trypanosoma brucei | RNA helicase, putative | 0.0617 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0268 | 0.2889 | 0.4869 |
Brugia malayi | nuclear hormone receptor | 0.0268 | 0.2889 | 0.4869 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0268 | 0.2889 | 0.2889 |
Loa Loa (eye worm) | hypothetical protein | 0.0268 | 0.2889 | 0.4869 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.0309 | 0.0521 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0142 | 0.0309 | 0.1071 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0268 | 0.2889 | 0.4869 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0268 | 0.2889 | 0.4869 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 2.1 ug ml-1 | Tested for growth inhibition activity against murine P388 lymphocytic leukemia | ChEMBL. | 15125958 |
Inhibition (functional) | = 2.1 ug ml-1 | Tested for growth inhibition activity against murine P388 lymphocytic leukemia | ChEMBL. | 15125958 |
Inhibition (functional) | = 4.6 ug ml-1 | Tested for growth inhibition activity against breast MCF-7 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | = 4.6 ug ml-1 | Tested for growth inhibition activity against breast MCF-7 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | = 6.7 ug ml-1 | Tested for growth inhibition activity against prostate DU-145 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | = 6.7 ug ml-1 | Tested for growth inhibition activity against prostate DU-145 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against pancreas BXPC-3 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against CNS SF-268 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against lung NCI-H460 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against colon KM20L2 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against pancreas BXPC-3 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against CNS SF-268 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against lung NCI-H460 human cancer cell | ChEMBL. | 15125958 |
Inhibition (functional) | > 10 ug ml-1 | Tested for growth inhibition activity against colon KM20L2 human cancer cell | ChEMBL. | 15125958 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.