Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin B | 0.0041 | 0.0346 | 0.0346 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0326 | 0.4423 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0099 | 0.0099 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0715 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0041 | 0.0346 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0041 | 0.0346 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0041 | 0.0346 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0715 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0715 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | cyclin 6, putative | 0.0041 | 0.0346 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0715 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0041 | 0.0346 | 0.0782 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0715 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0041 | 0.0346 | 0.0346 |
Giardia lamblia | Kinase, TTK | 0.0326 | 0.4423 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0041 | 0.0346 | 0.0782 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0041 | 0.0346 | 0.0346 |
Loa Loa (eye worm) | TTK protein kinase | 0.0326 | 0.4423 | 0.4423 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0041 | 0.0346 | 0.0782 |
Trichomonas vaginalis | cyclins, putative | 0.0041 | 0.0346 | 0.0782 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0326 | 0.4423 | 0.4423 |
Trypanosoma cruzi | cyclin, putative | 0.0041 | 0.0346 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0041 | 0.0346 | 0.0346 |
Echinococcus granulosus | cyclin B | 0.0041 | 0.0346 | 0.0346 |
Leishmania major | cyclin | 0.0041 | 0.0346 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0346 | 0.0346 |
Trichomonas vaginalis | cyclin B, putative | 0.0041 | 0.0346 | 0.0782 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0326 | 0.4423 | 0.4224 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0041 | 0.0346 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0041 | 0.0346 | 0.0782 |
Trichomonas vaginalis | cyclin A, putative | 0.0041 | 0.0346 | 0.0782 |
Trichomonas vaginalis | cyclins, putative | 0.0041 | 0.0346 | 0.0782 |
Trichomonas vaginalis | cyclins, putative | 0.0028 | 0.0158 | 0.0358 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0326 | 0.4423 | 0.4423 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0715 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0041 | 0.0346 | 0.0782 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0715 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0346 | 0.0346 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0326 | 0.4423 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0326 | 0.4423 | 0.4423 |
Trichomonas vaginalis | cyclin B, putative | 0.0041 | 0.0346 | 0.0782 |
Entamoeba histolytica | cyclin, putative | 0.0041 | 0.0346 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0326 | 0.4423 | 0.4423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.