Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0363 | 0.0822 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0321 | 0.4417 | 0.4417 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0363 | 0.0822 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0043 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | TTK protein kinase | 0.0321 | 0.4417 | 0.4417 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0043 | 0.0363 | 0.0822 |
Giardia lamblia | Kinase, TTK | 0.0321 | 0.4417 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0043 | 0.0363 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0703 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0363 | 0.0822 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0703 | 1 | 1 |
Schistosoma mansoni | cyclin B | 0.0043 | 0.0363 | 0.0363 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0703 | 1 | 1 |
Plasmodium falciparum | cyclin | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0703 | 1 | 1 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0043 | 0.0363 | 0.5 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0043 | 0.0363 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0043 | 0.0363 | 0.5 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0703 | 1 | 1 |
Echinococcus multilocularis | cyclin B | 0.0043 | 0.0363 | 0.0363 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 0.4417 | 1 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0321 | 0.4417 | 0.4417 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0363 | 0.0822 |
Entamoeba histolytica | cyclin, putative | 0.0043 | 0.0363 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0321 | 0.4417 | 0.4417 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0703 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0321 | 0.4417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0363 | 0.0363 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0321 | 0.4417 | 0.4417 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0703 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0363 | 0.0822 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0363 | 0.0822 |
Trichomonas vaginalis | cyclin A, putative | 0.0043 | 0.0363 | 0.0822 |
Trichomonas vaginalis | cyclins, putative | 0.0029 | 0.0166 | 0.0376 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0043 | 0.0363 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0043 | 0.0363 | 0.0822 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0363 | 0.0363 |
Trichomonas vaginalis | cyclin B, putative | 0.0043 | 0.0363 | 0.0822 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0321 | 0.4417 | 0.4206 |
Leishmania major | cyclin | 0.0043 | 0.0363 | 0.5 |
Trypanosoma cruzi | cyclin, putative | 0.0043 | 0.0363 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0043 | 0.0363 | 0.0363 |
Echinococcus granulosus | cyclin B | 0.0043 | 0.0363 | 0.0363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.