Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.062 | 0.0219 | 0.0219 | |
Onchocerca volvulus | Putative organic anion transporter | 0.062 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.062 | 0.0219 | 0.0219 | |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.062 | 0.0219 | 0.0219 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.062 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.062 | 0.0219 | 0.0219 | |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.062 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.9384 | 1 | 1 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.062 | 0.0219 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Onchocerca volvulus | Putative organic anion transporter | 0.9384 | 1 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.062 | 0.0219 | 0.0219 |
Schistosoma mansoni | organic anion transporter | 0.062 | 0.0219 | 1 |
Trypanosoma cruzi | MFS transporter, putative | 0.062 | 0.0219 | 0.5 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.062 | 0.0219 | 1 |
Brugia malayi | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.062 | 0.0219 | 0.0219 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.062 | 0.0219 | 1 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.062 | 0.0219 | 1 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.062 | 0.0219 | 1 |
Onchocerca volvulus | 0.062 | 0.0219 | 0.0219 | |
Onchocerca volvulus | 0.062 | 0.0219 | 0.0219 | |
Schistosoma mansoni | organic anion transporter | 0.062 | 0.0219 | 1 |
Brugia malayi | hypothetical protein | 0.062 | 0.0219 | 0.0219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 61 nM | Transactivation of human PPARgamma1 expressed in CHO-K1 cells co-expressing RXRalpha and PPRE after 1 day by luciferase reporter gene assay | ChEMBL. | 22503460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.