Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.053 | 0.7204 | 0.5 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0079 | 0 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.053 | 0.7204 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.053 | 0.7204 | 1 |
Giardia lamblia | Kinase, TTK | 0.053 | 0.7204 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.053 | 0.7204 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.053 | 0.7204 | 0.7204 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 0.9647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.8731 | 0.9051 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.053 | 0.7204 | 0.7204 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.053 | 0.7204 | 0.7204 |
Loa Loa (eye worm) | TTK protein kinase | 0.053 | 0.7204 | 0.7468 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0705 | 1 | 1 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0705 | 1 | 1 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.652 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.62 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.191 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.115 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.