Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 3 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 3 | 620 aa | 579 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0527 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0174 | 0.2866 | 0.0464 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 0.3039 | 0.0243 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0527 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 0.3039 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0174 | 0.2866 | 0.2866 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 0.3039 | 0.3039 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0174 | 0.2866 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3039 | 0.0243 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 0.3039 | 0.3039 |
Echinococcus granulosus | lysosomal protective protein | 0.0174 | 0.2866 | 0.0464 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 0.3039 | 0.0696 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3039 | 0.0243 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0174 | 0.2866 | 0.5 |
Onchocerca volvulus | 0.0182 | 0.3039 | 1 | |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 0.3039 | 0.0243 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0174 | 0.2866 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0174 | 0.2866 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 0.3039 | 0.0696 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0182 | 0.3039 | 0.0243 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3039 | 0.0243 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0174 | 0.2866 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0174 | 0.2866 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0527 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0174 | 0.2866 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0174 | 0.2866 | 0.2866 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0174 | 0.2866 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0527 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 0.3039 | 0.0243 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 3 uM | Displacement of [3H]WIN 35,428 from human dopamine active transporter | ChEMBL. | 22398259 |
IC50 (binding) | > 3 uM | Displacement of [3H]citalopram from human serotonin transporter | ChEMBL. | 22398259 |
Inhibition (binding) | Displacement of [3H]citalopram from human serotonin transporter | ChEMBL. | 22398259 | |
Inhibition (binding) | Displacement of [3H]WIN 35,428 from human dopamine active transporter | ChEMBL. | 22398259 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.