Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.35 uM | Inhibition of human recombinant DPP4 using H-Gly-Pro-7-amino-4-methylcoumarin as substrate assessed as inhibition of 7-amino-4-methylcoumarin formation after 30 mins by fluorimetry | ChEMBL. | 22377519 |
IC50 (functional) | = 0.44 uM | Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced response | ChEMBL. | 22377519 |
IC50 (binding) | > 50 uM | Inhibition of DPP8 | ChEMBL. | 22377519 |
IC50 (binding) | > 50 uM | Inhibition of DPP9 | ChEMBL. | 22377519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.