Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0215 | 0.0403 | 0.0881 |
Giardia lamblia | Cyclin A | 0.0419 | 0.094 | 0.5657 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0215 | 0.0403 | 0.0403 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0215 | 0.0403 | 0.5246 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0215 | 0.0403 | 0.0881 |
Echinococcus granulosus | cyclins | 0.0419 | 0.094 | 0.094 |
Echinococcus multilocularis | cyclin G2 | 0.0101 | 0.0105 | 0.0105 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Echinococcus multilocularis | cyclin G2 | 0.0101 | 0.0105 | 0.0105 |
Plasmodium falciparum | cyclin | 0.0419 | 0.094 | 1 |
Brugia malayi | Cyclin C | 0.0101 | 0.0105 | 0.03 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.093 | 0.2279 | 0.2279 |
Echinococcus multilocularis | cyclin dependent kinase 6 | 0.3873 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0664 | 0.158 | 0.4524 |
Echinococcus multilocularis | cyclin y | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | cyclin C | 0.0101 | 0.0105 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.158 | 0.4524 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0215 | 0.0403 | 0.0403 |
Trichomonas vaginalis | AGC family protein kinase | 0.1393 | 0.3493 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0664 | 0.158 | 0.4355 |
Brugia malayi | Protein kinase domain containing protein | 0.1393 | 0.3493 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0215 | 0.0403 | 0.0403 |
Echinococcus multilocularis | cyclin b3 | 0.0419 | 0.094 | 0.094 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0215 | 0.0403 | 0.1155 |
Toxoplasma gondii | hypothetical protein | 0.0318 | 0.0674 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0664 | 0.158 | 0.4355 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0067 | 0.0015 | 0.0042 |
Trichomonas vaginalis | cyclins, putative | 0.0664 | 0.158 | 0.4355 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.093 | 0.2279 | 0.6523 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Loa Loa (eye worm) | hypothetical protein | 0.0989 | 0.2435 | 0.6972 |
Echinococcus multilocularis | cyclin | 0.0101 | 0.0105 | 0.0105 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0664 | 0.158 | 0.6788 |
Schistosoma mansoni | cyclin B3 | 0.0419 | 0.094 | 0.094 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0419 | 0.094 | 0.269 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0215 | 0.0403 | 0.1374 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.093 | 0.2279 | 0.2279 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.093 | 0.2279 | 0.2279 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0664 | 0.158 | 0.6788 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0215 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0215 | 0.0403 | 0.0403 |
Trichomonas vaginalis | cyclin B, putative | 0.0664 | 0.158 | 0.4355 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0215 | 0.0403 | 0.0403 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Trichomonas vaginalis | cyclin A, putative | 0.0664 | 0.158 | 0.4355 |
Echinococcus granulosus | twitchin | 0.0108 | 0.0122 | 0.0122 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0215 | 0.0403 | 0.1374 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.093 | 0.2279 | 0.2279 |
Trichomonas vaginalis | AGC family protein kinase | 0.1393 | 0.3493 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0215 | 0.0403 | 0.0881 |
Echinococcus granulosus | cdk5 and abl1 enzyme substrate 1 | 0.0101 | 0.0105 | 0.0105 |
Echinococcus granulosus | cyclins | 0.0419 | 0.094 | 0.094 |
Echinococcus granulosus | cyclin B | 0.0664 | 0.158 | 0.158 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0215 | 0.0403 | 0.1155 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.1393 | 0.3493 | 0.3493 |
Echinococcus granulosus | cyclin B3 1 | 0.0419 | 0.094 | 0.094 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Trichomonas vaginalis | cyclin B, putative | 0.0419 | 0.094 | 0.2464 |
Trypanosoma cruzi | cyclin, putative | 0.0664 | 0.158 | 0.6788 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0215 | 0.0403 | 0.0403 |
Echinococcus granulosus | cyclin | 0.0101 | 0.0105 | 0.0105 |
Echinococcus granulosus | cyclin G2 | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.1393 | 0.3493 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1393 | 0.3493 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0215 | 0.0403 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0215 | 0.0403 | 0.2024 |
Echinococcus granulosus | cyclin y | 0.0101 | 0.0105 | 0.0105 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0101 | 0.0105 | 0.03 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Brugia malayi | cell division control protein 2 homolog | 0.0215 | 0.0403 | 0.1155 |
Echinococcus granulosus | cyclin b3 | 0.0419 | 0.094 | 0.094 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0419 | 0.094 | 0.2464 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0215 | 0.0403 | 0.1374 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0215 | 0.0403 | 0.1374 |
Echinococcus multilocularis | cyclin k | 0.0101 | 0.0105 | 0.0105 |
Echinococcus granulosus | cyclin A3 4 | 0.0101 | 0.0105 | 0.0105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0215 | 0.0403 | 0.0403 |
Echinococcus granulosus | cyclin G2 | 0.0101 | 0.0105 | 0.0105 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0105 | 0.03 |
Giardia lamblia | Hypothetical protein | 0.0419 | 0.094 | 0.5657 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.093 | 0.2279 | 1 |
Echinococcus granulosus | G1:S specific cyclin D1 | 0.0989 | 0.2435 | 0.2435 |
Echinococcus multilocularis | cyclin t1 | 0.0101 | 0.0105 | 0.0105 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0664 | 0.158 | 0.6788 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Trichomonas vaginalis | cyclin D, putative | 0.0419 | 0.094 | 0.2464 |
Echinococcus multilocularis | cdk5 and abl1 enzyme substrate 1 | 0.0101 | 0.0105 | 0.0105 |
Leishmania major | cyclin | 0.0664 | 0.158 | 0.6788 |
Trypanosoma cruzi | cyclin 6, putative | 0.0664 | 0.158 | 0.6788 |
Echinococcus multilocularis | G1:S specific cyclin D1 | 0.0989 | 0.2435 | 0.2435 |
Brugia malayi | cyclin fold protein 1 variant b | 0.0101 | 0.0105 | 0.03 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0664 | 0.158 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0664 | 0.158 | 0.4355 |
Echinococcus granulosus | cyclin k | 0.0101 | 0.0105 | 0.0105 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.1393 | 0.3493 | 1 |
Echinococcus granulosus | cyclin y | 0.0101 | 0.0105 | 0.0105 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0215 | 0.0403 | 0.0881 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | CYL-1 protein | 0.0101 | 0.0105 | 0.03 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0215 | 0.0403 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.048 | 0.1375 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0215 | 0.0403 | 0.1374 |
Schistosoma mansoni | cyclin l | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.093 | 0.2279 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0419 | 0.094 | 0.269 |
Brugia malayi | P38 map kinase family protein 2 | 0.093 | 0.2279 | 0.6523 |
Loa Loa (eye worm) | cyclin fold protein 1 variant b | 0.0101 | 0.0105 | 0.03 |
Entamoeba histolytica | cyclin, putative | 0.0419 | 0.094 | 0.2464 |
Onchocerca volvulus | 0.0664 | 0.158 | 1 | |
Brugia malayi | hypothetical protein | 0.0101 | 0.0105 | 0.03 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0105 | 0.03 |
Schistosoma mansoni | Cyclin fold protein | 0.0101 | 0.0105 | 0.0105 |
Entamoeba histolytica | protein kinase, putative | 0.1393 | 0.3493 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0419 | 0.094 | 0.2464 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.1393 | 0.3493 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0105 | 0.0105 |
Giardia lamblia | Kinase, CMGC CDK | 0.0215 | 0.0403 | 0.2024 |
Trichomonas vaginalis | cyclin B3, putative | 0.0419 | 0.094 | 0.2464 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0419 | 0.094 | 0.094 |
Echinococcus granulosus | cyclins | 0.0419 | 0.094 | 0.094 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0067 | 0.0015 | 0.0042 |
Echinococcus multilocularis | cyclin B3 1 | 0.0419 | 0.094 | 0.094 |
Plasmodium falciparum | protein kinase 5 | 0.0215 | 0.0403 | 0.3577 |
Entamoeba histolytica | cyclin family protein | 0.0419 | 0.094 | 0.2464 |
Schistosoma mansoni | cyclin d | 0.0989 | 0.2435 | 0.2435 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.093 | 0.2279 | 1 |
Echinococcus granulosus | cyclins | 0.0419 | 0.094 | 0.094 |
Echinococcus granulosus | cyclins | 0.0419 | 0.094 | 0.094 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0215 | 0.0403 | 0.0881 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0215 | 0.0403 | 0.1374 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0215 | 0.0403 | 0.1374 |
Trichomonas vaginalis | cyclins, putative | 0.0664 | 0.158 | 0.4355 |
Entamoeba histolytica | cyclin, putative | 0.0664 | 0.158 | 0.4355 |
Schistosoma mansoni | cyclins | 0.0419 | 0.094 | 0.094 |
Schistosoma mansoni | cyclin B | 0.0664 | 0.158 | 0.158 |
Echinococcus multilocularis | cyclin y | 0.0101 | 0.0105 | 0.0105 |
Trypanosoma cruzi | cyclin, putative | 0.0664 | 0.158 | 0.6788 |
Echinococcus granulosus | cyclin dependent kinase | 0.0215 | 0.0403 | 0.0403 |
Schistosoma mansoni | cyclin G2 | 0.0101 | 0.0105 | 0.0105 |
Trichomonas vaginalis | cyclin B, putative | 0.0664 | 0.158 | 0.4355 |
Schistosoma mansoni | cyclin G | 0.0101 | 0.0105 | 0.0105 |
Schistosoma mansoni | serine/threonine protein kinase | 0.3873 | 1 | 1 |
Echinococcus granulosus | Cyclin L1 | 0.0101 | 0.0105 | 0.0105 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.093 | 0.2279 | 0.2279 |
Trichomonas vaginalis | cyclin B, putative | 0.0664 | 0.158 | 0.4355 |
Trichomonas vaginalis | cyclins, putative | 0.0345 | 0.0746 | 0.1892 |
Echinococcus multilocularis | Cyclin L1 | 0.0101 | 0.0105 | 0.0105 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0419 | 0.094 | 0.094 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0989 | 0.2435 | 0.6972 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.1393 | 0.3493 | 0.3493 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1393 | 0.3493 | 0.3493 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Echinococcus multilocularis | cyclin B | 0.0664 | 0.158 | 0.158 |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.0101 | 0.0105 | 0.0105 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0105 | 0.0105 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0215 | 0.0403 | 0.0403 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0664 | 0.158 | 0.4524 |
Brugia malayi | Protein kinase domain containing protein | 0.0215 | 0.0403 | 0.1155 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0664 | 0.158 | 0.4524 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0215 | 0.0403 | 0.1155 |
Echinococcus granulosus | cyclin t1 | 0.0101 | 0.0105 | 0.0105 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.093 | 0.2279 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.093 | 0.2279 | 0.2279 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Entamoeba histolytica | cyclin family protein | 0.0419 | 0.094 | 0.2464 |
Echinococcus multilocularis | cyclins | 0.0419 | 0.094 | 0.094 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0101 | 0.0105 | 0.03 |
Trichomonas vaginalis | cyclin D, putative | 0.0419 | 0.094 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0282 | 0.0807 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0101 | 0.0105 | 0.0105 |
Echinococcus multilocularis | cyclin A3 4 | 0.0101 | 0.0105 | 0.0105 |
Loa Loa (eye worm) | hypothetical protein | 0.0888 | 0.217 | 0.6212 |
Echinococcus granulosus | cyclins | 0.0101 | 0.0105 | 0.0105 |
Schistosoma mansoni | cyclin k | 0.0101 | 0.0105 | 0.0105 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.