Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | cystatin | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0007 | 0.5 | 0.5 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | cystatin B | 0.0007 | 0.5 | 0.5 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.5 | 0.5 |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0007 | 0.5 | 0.5 |
Echinococcus granulosus | Cystatin B Stefin B | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Loa Loa (eye worm) | cystatin | 0.0007 | 0.5 | 0.5 |
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0007 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0007 | 0.5 | 0.5 | |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0007 | 0.5 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.