Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.005 | 0.0092 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0039 | 0.0039 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2209 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | c src tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0039 | 0.0039 | 0.0039 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2209 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2209 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.2209 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0092 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2209 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2209 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2209 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2209 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0039 | 0.0039 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.1284 | 0.5755 | 0.5755 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0039 | 0.0039 | 0.4236 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2209 | 1 | 0.5 |
Brugia malayi | SRC-1 | 0.0039 | 0.0039 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.1314 | 0.5894 | 0.5894 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2209 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2209 | 1 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Brugia malayi | SH2 domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0059 | 0.0131 | 0.0131 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.1314 | 0.5894 | 0.5894 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2209 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2209 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2209 | 1 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0039 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0039 | 0.0039 | 0.0039 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2209 | 1 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0039 | 0.0039 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0039 | 0.0039 | 0.0039 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2209 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | protein-tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Schistosoma mansoni | tyrosine kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2209 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2209 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Brugia malayi | SH2 domain containing protein | 0.0039 | 0.0039 | 0.0039 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0039 | 0.0039 | 0.0039 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.1314 | 0.5894 | 0.5894 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.