Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | heat shock protein, putative | 0.0378 | 0.3132 | 0.655 |
Brugia malayi | Endoplasmin precursor | 0.0474 | 0.4783 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0474 | 0.4783 | 1 |
Echinococcus multilocularis | heat shock protein | 0.0474 | 0.4783 | 0.4783 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Echinococcus granulosus | endoplasmin | 0.0378 | 0.3132 | 0.3132 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0378 | 0.3132 | 0.5 |
Schistosoma mansoni | endoplasmin | 0.0474 | 0.4783 | 0.4783 |
Echinococcus granulosus | heat shock protein 90 | 0.0474 | 0.4783 | 0.4783 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0194 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0378 | 0.3132 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0378 | 0.3132 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0291 | 0.165 | 0.345 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.078 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Echinococcus granulosus | heat shock protein | 0.0474 | 0.4783 | 0.4783 |
Treponema pallidum | heat shock protein 90 | 0.0378 | 0.3132 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0474 | 0.4783 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0378 | 0.3132 | 0.3132 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0474 | 0.4783 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0474 | 0.4783 | 1 |
Brugia malayi | heat shock protein 90 | 0.0474 | 0.4783 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0378 | 0.3132 | 0.3132 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.028 | 0.1463 | 0.3058 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.078 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0474 | 0.4783 | 0.4783 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0378 | 0.3132 | 0.3132 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0378 | 0.3132 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0378 | 0.3132 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0291 | 0.165 | 0.345 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Schistosoma mansoni | heat shock protein | 0.0474 | 0.4783 | 0.4783 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0474 | 0.4783 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0378 | 0.3132 | 0.3132 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0474 | 0.4783 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0474 | 0.4783 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0474 | 0.4783 | 0.4783 |
Plasmodium vivax | endoplasmin, putative | 0.0474 | 0.4783 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0378 | 0.3132 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0474 | 0.4783 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0378 | 0.3132 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Schistosoma mansoni | heat shock protein | 0.0474 | 0.4783 | 0.4783 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0378 | 0.3132 | 0.655 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0474 | 0.4783 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0291 | 0.165 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0474 | 0.4783 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0378 | 0.3132 | 0.655 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0474 | 0.4783 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0474 | 0.4783 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.685 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.661 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.602 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.581 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.55 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.468 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.259 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.15 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.