Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | heat shock protein 84, putative | 0.0165 | 0.2588 | 0.2588 |
Schistosoma mansoni | heat shock protein | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.032 | 0.7443 | 0.7443 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 75 kDa, mitochondrial | 0.0165 | 0.2588 | 0.2588 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.032 | 0.7443 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.032 | 0.7443 | 0.7443 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0165 | 0.2588 | 0.2588 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.032 | 0.7443 | 0.7443 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0402 | 1 | 1 |
Plasmodium vivax | heat shock protein 90, putative | 0.0165 | 0.2588 | 0.2588 |
Loa Loa (eye worm) | endoplasmin | 0.0402 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0165 | 0.2588 | 0.2588 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.032 | 0.7443 | 0.7443 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.032 | 0.7443 | 0.7443 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Brugia malayi | heat shock protein 90 | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0237 | 0.4855 | 0.4855 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0165 | 0.2588 | 0.2588 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0082 | 0 | 0.5 |
Brugia malayi | Hsp90 protein | 0.0165 | 0.2588 | 0.2588 |
Leishmania major | heat shock protein, putative | 0.0165 | 0.2588 | 0.2588 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Echinococcus multilocularis | endoplasmin | 0.032 | 0.7443 | 0.7443 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0402 | 1 | 1 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.032 | 0.7443 | 0.7443 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Toxoplasma gondii | Hsp90 domain-containing protein | 0.0165 | 0.2588 | 0.2588 |
Loa Loa (eye worm) | heat shock protein 75 | 0.0165 | 0.2588 | 0.2588 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.032 | 0.7443 | 0.7443 |
Schistosoma mansoni | heat shock protein | 0.0402 | 1 | 1 |
Treponema pallidum | heat shock protein 90 | 0.032 | 0.7443 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.032 | 0.7443 | 1 |
Echinococcus multilocularis | heat shock protein | 0.0402 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.032 | 0.7443 | 0.7443 |
Trypanosoma cruzi | heat shock protein, putative | 0.0165 | 0.2588 | 0.2588 |
Mycobacterium ulcerans | heat shock protein 90 | 0.032 | 0.7443 | 1 |
Plasmodium falciparum | heat shock protein 90, putative | 0.0165 | 0.2588 | 0.2588 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0402 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.032 | 0.7443 | 0.7443 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0165 | 0.2588 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Toxoplasma gondii | heat shock protein 75, putative | 0.0165 | 0.2588 | 0.2588 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0402 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0246 | 0.5145 | 0.5145 |
Trichomonas vaginalis | heat shock protein, putative | 0.0402 | 1 | 1 |
Plasmodium vivax | heat shock protein, putative | 0.0165 | 0.2588 | 0.2588 |
Giardia lamblia | Grp94/Hsp90 | 0.032 | 0.7443 | 0.7443 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.032 | 0.7443 | 0.7443 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.0082 | 0 | 0.5 |
Entamoeba histolytica | 90 kDa heat shock protein, putative | 0.0165 | 0.2588 | 0.2588 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.032 | 0.7443 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0246 | 0.5145 | 0.5145 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0402 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.032 | 0.7443 | 0.7443 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0402 | 1 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0402 | 1 | 1 |
Echinococcus granulosus | heat shock protein 90 | 0.0402 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0246 | 0.5145 | 0.5145 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Echinococcus granulosus | heat shock protein 75 kDa mitochondrial | 0.0165 | 0.2588 | 0.2588 |
Leishmania major | heat shock protein 83-1 | 0.0402 | 1 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0402 | 1 | 1 |
Plasmodium falciparum | heat shock protein 90 | 0.0402 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0402 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0402 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.