TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.549 | Formula: C22H39NO4
H donors: 3 H acceptors: 3 LogP: 2.92 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1N(CCCCCOCC23CC4CC(C3)CC(C2)C4)CC[C@H]([C@@H]1O)O
InChi: 1S/C22H39NO4/c24-14-19-21(26)20(25)4-6-23(19)5-2-1-3-7-27-15-22-11-16-8-17(12-22)10-18(9-16)13-22/h16-21,24-26H,1-15H2/t16?,17?,18?,19-,20-,21-,22?/m1/s1
InChiKey: VIZUYNYAIYKSCL-QUISSDDZSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucosidase, beta (bile acid) 2	Starlite/ChEMBL	References
Mus musculus	UDP-glucose ceramide glucosyltransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Echinococcus granulosus	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Echinococcus granulosus	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Echinococcus granulosus	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	Ceramide glucosyltransferase, putative	Get druggable targets OG5_129848	All targets in OG5_129848
Brugia malayi	Ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Onchocerca volvulus	Ceramide glucosyltransferase homolog	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Echinococcus multilocularis	bile acid beta glucosidase	Get druggable targets OG5_130651	All targets in OG5_130651
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	bile acid beta-glucosidase-related	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma japonicum	ko:K00720 ceramide glucosyltransferase [EC2.4.1.80], putative	Get druggable targets OG5_129848	All targets in OG5_129848
Schistosoma japonicum	Non-lysosomal glucosylceramidase, putative	Get druggable targets OG5_130651	All targets in OG5_130651
Schistosoma mansoni	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Candida albicans	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848
Echinococcus multilocularis	non lysosomal glucosylceramidase	Get druggable targets OG5_130651	All targets in OG5_130651
Echinococcus multilocularis	ceramide glucosyltransferase	Get druggable targets OG5_129848	All targets in OG5_129848

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TKL/STKR/TYPE2 protein kinase	0.0572	0.1046	0.1046
Echinococcus granulosus	ceramide glucosyltransferase	0.0288	0.0377	0.0381
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0479	0.0827	0.0827
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0216	0.0207	0.021
Echinococcus multilocularis	ceramide glucosyltransferase	0.0288	0.0377	0.0381
Loa Loa (eye worm)	ceramide glucosyltransferase	0.0288	0.0377	0.0377
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0572	0.1046	0.1046
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0249	0.0285	0.0288
Trypanosoma cruzi	cdc2-related kinase 1	0.0479	0.0827	1
Entamoeba histolytica	protein kinase, putative	0.0128	0.00000012288	0.0000014862
Schistosoma mansoni	protein kinase	0.0137	0.0021	0.0022
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0216	0.0207	0.021
Plasmodium falciparum	protein kinase 5	0.0479	0.0827	1
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Loa Loa (eye worm)	hypothetical protein	0.017	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0787	0.1553	0.1553
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0155	0.0063	0.0063
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.0251	0.029	0.0294
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0155	0.0063	0.0764
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0216	0.0207	0.021
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.00000012288	0.0000014862
Echinococcus granulosus	tyrosine protein kinase Srms	0.0216	0.0207	0.021
Echinococcus granulosus	TGF beta receptor type 1	0.1473	0.3171	0.3208
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0137	0.0021	0.0022
Brugia malayi	Ceramide glucosyltransferase	0.0288	0.0377	0.0377
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0216	0.0207	0.021
Giardia lamblia	Ceramide glucosyltransferase	0.0131	0.0006	0.0067
Echinococcus granulosus	mitogen activated protein kinase 11	0.0155	0.0063	0.0064
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0155	0.0063	0.0764
Echinococcus granulosus	c src tyrosine kinase	0.0216	0.0207	0.021
Echinococcus multilocularis	cyclin dependent kinase 1	0.0479	0.0827	0.0837
Echinococcus multilocularis	GPCR, family 2	0.0249	0.0285	0.0288
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0216	0.0207	0.021
Schistosoma mansoni	serine/threonine protein kinase	0.0479	0.0827	0.0837
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0787	0.1553	0.1553
Echinococcus granulosus	tyrosine protein kinase shark	0.0216	0.0207	0.021
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Brugia malayi	SH2 domain containing protein	0.0216	0.0207	0.0207
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.00000012288	0.0000014862
Echinococcus granulosus	tyrosine kinase	0.0216	0.0207	0.021
Brugia malayi	protein C17H12.11	0.0563	0.1025	0.1025
Brugia malayi	P38 map kinase family protein 2	0.0155	0.0063	0.0063
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.00000012288	0.0000014862
Entamoeba histolytica	cell division protein kinase 2, putative	0.0479	0.0827	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0479	0.0827	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0249	0.0285	0.0288
Echinococcus granulosus	activin receptor type	0.0797	0.1577	0.1596
Schistosoma mansoni	protein kinase	0.2682	0.602	0.6092
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0479	0.0827	0.0827
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0249	0.0285	0.0285
Echinococcus multilocularis	bile acid beta glucosidase	0.0251	0.029	0.0294
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0216	0.0207	0.251
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0216	0.0207	0.021
Echinococcus multilocularis	cyclin dependent kinase	0.0479	0.0827	0.0837
Echinococcus multilocularis	serine:threonine protein kinase receptor R3	0.0669	0.1275	0.129
Onchocerca volvulus		0.0216	0.0207	0.5508
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Onchocerca volvulus		0.0216	0.0207	0.5508
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0216	0.0207	0.021
Trypanosoma brucei	cdc2-related kinase 3	0.0479	0.0827	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0216	0.0207	0.021
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0128	0.00000012288	0.0000014862
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Loa Loa (eye worm)	TK/FAK protein kinase	0.4371	1	1
Brugia malayi	Protein kinase domain containing protein	0.0216	0.0207	0.0207
Echinococcus granulosus	cyclin dependent kinase	0.0479	0.0827	0.0837
Brugia malayi	Protein kinase domain containing protein	0.0216	0.0207	0.0207
Echinococcus multilocularis	tyrosine kinase	0.0216	0.0207	0.021
Schistosoma mansoni	protein kinase	0.2682	0.602	0.6092
Echinococcus multilocularis	c src tyrosine kinase	0.0216	0.0207	0.021
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0137	0.0021	0.0259
Trypanosoma brucei	protein kinase, putative	0.0137	0.0021	0.0259
Echinococcus granulosus	bile acid beta glucosidase	0.0251	0.029	0.0294
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0216	0.0207	0.021
Echinococcus granulosus	integrin linked protein kinase	0.2682	0.602	0.6092
Trichomonas vaginalis	CMGC family protein kinase	0.0479	0.0827	1
Echinococcus multilocularis	protein tyrosine kinase	0.4321	0.9882	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0249	0.0285	0.0285
Echinococcus granulosus	mitogen activated protein kinase 14	0.0155	0.0063	0.0064
Echinococcus multilocularis	integrin linked protein kinase	0.2682	0.602	0.6092
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0479	0.0827	0.0827
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1025	0.1025
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0216	0.0207	0.021
Schistosoma mansoni	serine/threonine protein kinase	0.0479	0.0827	0.0837
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0216	0.0207	0.021
Trypanosoma cruzi	cdc2-related kinase 3	0.0479	0.0827	1
Schistosoma mansoni	protein kinase	0.0788	0.1556	0.1575
Loa Loa (eye worm)	TK protein kinase	0.0216	0.0207	0.0207
Giardia lamblia	Protein 21.1	0.0128	0.00000012288	0.0000014862
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0216	0.0207	0.021
Schistosoma mansoni	protein kinase	0.0137	0.0021	0.0022
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0787	0.1553	0.1553
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.047	0.0805	0.0805
Brugia malayi	Protein kinase domain containing protein	0.0572	0.1046	0.1046
Loa Loa (eye worm)	SRC-1	0.0216	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0216	0.0207	0.021
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0155	0.0063	0.0764
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0137	0.0021	0.0022
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0128	0.00000012288	0.00000012288
Entamoeba histolytica	ankyrin repeat protein	0.0128	0.00000012288	0.0000014862
Giardia lamblia	Kinase, CMGC CDK	0.0479	0.0827	1
Trichomonas vaginalis	CMGC family protein kinase	0.0479	0.0827	1
Echinococcus granulosus	TGF-beta receptor type-1	0.1473	0.3171	0.3208
Echinococcus granulosus	tyrosine protein kinase Blk	0.0216	0.0207	0.021
Brugia malayi	cell division control protein 2 homolog	0.0479	0.0827	0.0827
Brugia malayi	Protein kinase domain containing protein	0.0128	0.00000012288	0.00000012288
Schistosoma mansoni	tyrosine kinase	0.4321	0.9882	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0538	0.0966	0.0966
Loa Loa (eye worm)	hypothetical protein	0.0538	0.0966	0.0966
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Brugia malayi	Protein kinase domain containing protein	0.0216	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0225	0.0229	0.0232
Schistosoma mansoni	hypothetical protein	0.0249	0.0285	0.0288
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0137	0.0021	0.0259
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0155	0.0063	0.0064
Onchocerca volvulus		0.0216	0.0207	0.5508
Entamoeba histolytica	protein kinase, putative	0.0128	0.00000012288	0.0000014862
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.2682	0.602	0.602
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.029	0.0294
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0137	0.0021	0.0259
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Brugia malayi	Protein kinase domain containing protein	0.0216	0.0207	0.0207
Giardia lamblia	Kinase, NEK	0.0128	0.00000012288	0.0000014862
Schistosoma mansoni	tyrosine kinase	0.0216	0.0207	0.021
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0216	0.0207	0.021
Brugia malayi	hypothetical protein	0.0216	0.0207	0.0207
Brugia malayi	Tyrosine-protein kinase abl-1	0.0216	0.0207	0.0207
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0216	0.0207	0.021
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0479	0.0827	1
Brugia malayi	hypothetical protein	0.0563	0.1025	0.1025
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0216	0.0207	0.021
Brugia malayi	protein-tyrosine kinase	0.0216	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0216	0.0207	0.021
Schistosoma mansoni	hypothetical protein	0.0249	0.0285	0.0288
Schistosoma mansoni	hypothetical protein	0.0249	0.0285	0.0288
Brugia malayi	SRC-1	0.0216	0.0207	0.0207
Giardia lamblia	Kinase, CMGC CDK	0.0479	0.0827	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0479	0.0827	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.1592	0.3451	0.3451
Schistosoma mansoni	hypothetical protein	0.0538	0.0966	0.0977
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0479	0.0827	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Brugia malayi	Protein kinase domain containing protein	0.0479	0.0827	0.0827
Schistosoma mansoni	protein kinase	0.0137	0.0021	0.0022
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Schistosoma mansoni	hypothetical protein	0.0249	0.0285	0.0288
Echinococcus multilocularis	cyclin dependent kinase 5	0.0479	0.0827	0.0837
Brugia malayi	Latrophilin receptor protein 2	0.0249	0.0285	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0285	0.0285
Brugia malayi	integrin-linked kinase	0.2682	0.602	0.602
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0155	0.0063	0.0064
Echinococcus multilocularis	TGF beta receptor type 1	0.1473	0.3171	0.3208
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0249	0.0285	0.0288
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0155	0.0063	0.0064
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0155	0.0063	0.0064
Trichomonas vaginalis	CMGC family protein kinase	0.0479	0.0827	1
Onchocerca volvulus		0.0216	0.0207	0.5508
Echinococcus granulosus	non lysosomal glucosylceramidase	0.0251	0.029	0.0294
Schistosoma mansoni	bile acid beta-glucosidase-related	0.0251	0.029	0.0294
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.0377	0.0381
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Brugia malayi	bone morphogenetic protein type 1 receptor	0.1592	0.3451	0.3451
Echinococcus granulosus	cyclin dependent kinase 5	0.0479	0.0827	0.0837
Echinococcus granulosus	cyclin dependent kinase 1	0.0479	0.0827	0.0837
Echinococcus multilocularis	tyrosine protein kinase shark	0.0216	0.0207	0.021
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0787	0.1553	0.1553
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0249	0.0285	0.0288
Echinococcus granulosus	protein tyrosine kinase	0.4321	0.9882	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0479	0.0827	0.0837
Entamoeba histolytica	protein kinase domain containing protein	0.0137	0.0021	0.0259
Onchocerca volvulus		0.0216	0.0207	0.5508
Onchocerca volvulus		0.0128	0.00000012288	0.0000032619
Loa Loa (eye worm)	hypothetical protein	0.0216	0.0207	0.0207
Schistosoma mansoni	ceramide glucosyltransferase	0.0288	0.0377	0.0381
Echinococcus multilocularis	cyclin dependent kinase 1	0.0479	0.0827	0.0837
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.0288	0.0377	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0216	0.0207	0.021
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Onchocerca volvulus		0.0216	0.0207	0.5508
Leishmania major	protein kinase, putative	0.0137	0.0021	0.0259
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0216	0.0207	0.021
Trichomonas vaginalis	TKL family protein kinase	0.0128	0.00000012288	0.0000014862
Loa Loa (eye worm)	TK/ABL protein kinase	0.0216	0.0207	0.0207
Trypanosoma brucei	cdc2-related kinase 1	0.0479	0.0827	1
Echinococcus granulosus	GPCR family 2	0.0249	0.0285	0.0288
Brugia malayi	SH2 domain containing protein	0.0216	0.0207	0.0207
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Trypanosoma cruzi	cdc2-related kinase 3	0.0479	0.0827	1
Plasmodium vivax	protein kinase Crk2	0.0479	0.0827	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0137	0.0021	0.0259
Echinococcus multilocularis	activin receptor type	0.0797	0.1577	0.1596
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0155	0.0063	0.0764
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0216	0.0207	0.021
Brugia malayi	Protein kinase domain containing protein	0.0216	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0216	0.0207	0.021
Plasmodium falciparum	protein kinase, putative	0.0137	0.0021	0.0259
Entamoeba histolytica	cell division protein kinase 2, putative	0.0479	0.0827	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0216	0.0207	0.0207
Echinococcus granulosus	tyrosine kinase	0.0216	0.0207	0.021
Schistosoma mansoni	protein kinase	0.1473	0.3171	0.3208

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1 uM	Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysis	ChEMBL.	24900342
IC50 (binding)	> 10 uM	Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence scanner	ChEMBL.	24900342
Inhibition (binding)		Inhibition of glucosylceramide synthase in mouse RAW cells up to 20 uM preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence scanner	ChEMBL.	24900342

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2011626

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1639521