Detailed information for compound 1639538

Basic information

Technical information
  • TDR Targets ID: 1639538
  • Name: (E)-5-dimethylamino-1-(4-methylphenyl)pent-1- en-3-one
  • MW: 217.307 | Formula: C14H19NO
  • H donors: 0 H acceptors: 1 LogP: 2.37 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCC(=O)/C=C/c1ccc(cc1)C)C
  • InChi: 1S/C14H19NO/c1-12-4-6-13(7-5-12)8-9-14(16)10-11-15(2)3/h4-9H,10-11H2,1-3H3/b9-8+
  • InChiKey: AIIDBIJYDKABIO-CMDGGOBGSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-dimethylamino-1-(4-methylphenyl)pent-1-en-3-one
  • NCI60_005634

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0101 0.0105 0.0105
Echinococcus granulosus cyclin dependent kinase 5 0.0215 0.0403 0.0403
Brugia malayi Cyclin, N-terminal domain containing protein 0.0664 0.158 0.4524
Brugia malayi Protein kinase domain containing protein 0.0215 0.0403 0.1155
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0101 0.0105 0.0105
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0215 0.0403 0.1155
Loa Loa (eye worm) hypothetical protein 0.0664 0.158 0.4524
Echinococcus granulosus cyclin t1 0.0101 0.0105 0.0105
Brugia malayi Cyclin, N-terminal domain containing protein 0.0989 0.2435 0.6972
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.1393 0.3493 0.3493
Schistosoma mansoni serine/threonine protein kinase 0.1393 0.3493 0.3493
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Echinococcus multilocularis cyclin B 0.0664 0.158 0.158
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0101 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0888 0.217 0.6212
Echinococcus granulosus cyclins 0.0101 0.0105 0.0105
Schistosoma mansoni cyclin k 0.0101 0.0105 0.0105
Echinococcus multilocularis mitogen activated protein kinase 11 0.093 0.2279 0.2279
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.093 0.2279 1
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Entamoeba histolytica cyclin family protein 0.0419 0.094 0.2464
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Loa Loa (eye worm) hypothetical protein 0.0169 0.0282 0.0807
Trichomonas vaginalis cyclin D, putative 0.0419 0.094 0.2464
Schistosoma mansoni g1/s-specific cyclin C 0.0101 0.0105 0.0105
Echinococcus multilocularis cyclin A3 4 0.0101 0.0105 0.0105
Trypanosoma cruzi cyclin, putative 0.0664 0.158 0.6788
Echinococcus granulosus cyclin dependent kinase 0.0215 0.0403 0.0403
Schistosoma mansoni cyclin G2 0.0101 0.0105 0.0105
Echinococcus multilocularis cyclin y 0.0101 0.0105 0.0105
Echinococcus multilocularis mitogen activated protein kinase 14 0.093 0.2279 0.2279
Trichomonas vaginalis cyclin B, putative 0.0664 0.158 0.4355
Trichomonas vaginalis cyclins, putative 0.0345 0.0746 0.1892
Echinococcus multilocularis Cyclin L1 0.0101 0.0105 0.0105
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0419 0.094 0.094
Trichomonas vaginalis cyclin B, putative 0.0664 0.158 0.4355
Schistosoma mansoni cyclin G 0.0101 0.0105 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.3873 1 1
Echinococcus granulosus Cyclin L1 0.0101 0.0105 0.0105
Trichomonas vaginalis cyclins, putative 0.0419 0.094 0.2464
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.1393 0.3493 1
Schistosoma mansoni hypothetical protein 0.0101 0.0105 0.0105
Giardia lamblia Kinase, CMGC CDK 0.0215 0.0403 0.2024
Trichomonas vaginalis cyclin B3, putative 0.0419 0.094 0.2464
Onchocerca volvulus 0.0664 0.158 1
Brugia malayi hypothetical protein 0.0101 0.0105 0.03
Loa Loa (eye worm) hypothetical protein 0.0101 0.0105 0.03
Entamoeba histolytica protein kinase, putative 0.1393 0.3493 1
Schistosoma mansoni Cyclin fold protein 0.0101 0.0105 0.0105
Echinococcus granulosus cyclins 0.0419 0.094 0.094
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.093 0.2279 1
Echinococcus granulosus cyclins 0.0419 0.094 0.094
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0403 0.0881
Trypanosoma cruzi cdc2-related kinase 1 0.0215 0.0403 0.1374
Trypanosoma cruzi cdc2-related kinase 3 0.0215 0.0403 0.1374
Trichomonas vaginalis cyclins, putative 0.0664 0.158 0.4355
Entamoeba histolytica cyclin, putative 0.0664 0.158 0.4355
Schistosoma mansoni cyclins 0.0419 0.094 0.094
Schistosoma mansoni cyclin B 0.0664 0.158 0.158
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0419 0.094 0.094
Echinococcus granulosus cyclins 0.0419 0.094 0.094
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0067 0.0015 0.0042
Echinococcus multilocularis cyclin B3 1 0.0419 0.094 0.094
Plasmodium falciparum protein kinase 5 0.0215 0.0403 0.3577
Entamoeba histolytica cyclin family protein 0.0419 0.094 0.2464
Schistosoma mansoni cyclin d 0.0989 0.2435 0.2435
Leishmania major cyclin 0.0664 0.158 0.6788
Trypanosoma cruzi cyclin 6, putative 0.0664 0.158 0.6788
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0101 0.0105 0.0105
Echinococcus multilocularis G1:S specific cyclin D1 0.0989 0.2435 0.2435
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Trichomonas vaginalis cyclin D, putative 0.0419 0.094 0.2464
Trypanosoma brucei cdc2-related kinase 3 0.0215 0.0403 0.1374
Schistosoma mansoni cyclin l 0.0101 0.0105 0.0105
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.093 0.2279 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0419 0.094 0.269
Brugia malayi P38 map kinase family protein 2 0.093 0.2279 0.6523
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0101 0.0105 0.03
Entamoeba histolytica cyclin, putative 0.0419 0.094 0.2464
Brugia malayi cyclin fold protein 1 variant b 0.0101 0.0105 0.03
Trichomonas vaginalis cyclin B, putative 0.0664 0.158 0.4355
Echinococcus granulosus cyclin k 0.0101 0.0105 0.0105
Giardia lamblia G2/mitotic-specific cyclin B 0.0664 0.158 1
Echinococcus granulosus cyclin y 0.0101 0.0105 0.0105
Brugia malayi phosphoinositide-dependent protein kinase I 0.1393 0.3493 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0215 0.0403 0.0881
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0101 0.0105 0.0105
Loa Loa (eye worm) CYL-1 protein 0.0101 0.0105 0.03
Loa Loa (eye worm) hypothetical protein 0.0244 0.048 0.1375
Trypanosoma cruzi cdc2-related kinase 3 0.0215 0.0403 0.1374
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Trypanosoma brucei cdc2-related kinase 1 0.0215 0.0403 0.1374
Echinococcus granulosus cyclin A3 4 0.0101 0.0105 0.0105
Echinococcus multilocularis cyclin k 0.0101 0.0105 0.0105
Trichomonas vaginalis AGC family protein kinase 0.1393 0.3493 1
Plasmodium vivax protein kinase Crk2 0.0215 0.0403 1
Giardia lamblia Kinase, CMGC CDK 0.0215 0.0403 0.2024
Echinococcus granulosus cyclin y 0.0101 0.0105 0.0105
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Brugia malayi cell division control protein 2 homolog 0.0215 0.0403 0.1155
Echinococcus granulosus cyclin b3 0.0419 0.094 0.094
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0215 0.0403 0.1374
Trichomonas vaginalis conserved hypothetical protein 0.0419 0.094 0.2464
Echinococcus multilocularis cyclin t1 0.0101 0.0105 0.0105
Trypanosoma cruzi CYC2-like cyclin, putative 0.0664 0.158 0.6788
Echinococcus granulosus cyclin G2 0.0101 0.0105 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0403 0.0403
Brugia malayi hypothetical protein 0.0101 0.0105 0.03
Giardia lamblia Hypothetical protein 0.0419 0.094 0.5657
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.093 0.2279 1
Echinococcus granulosus G1:S specific cyclin D1 0.0989 0.2435 0.2435
Echinococcus granulosus cyclin B 0.0664 0.158 0.158
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0215 0.0403 0.1155
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.1393 0.3493 0.3493
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0215 0.0403 0.1374
Echinococcus multilocularis mitogen activated protein kinase 11 0.093 0.2279 0.2279
Trichomonas vaginalis AGC family protein kinase 0.1393 0.3493 1
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0403 0.0881
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0101 0.0105 0.0105
Echinococcus granulosus cyclins 0.0419 0.094 0.094
Schistosoma mansoni serine/threonine protein kinase 0.0215 0.0403 0.0403
Echinococcus granulosus cyclin G2 0.0101 0.0105 0.0105
Echinococcus granulosus cyclin 0.0101 0.0105 0.0105
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.1393 0.3493 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Echinococcus granulosus cyclin B3 1 0.0419 0.094 0.094
Trichomonas vaginalis cyclin B, putative 0.0419 0.094 0.2464
Trypanosoma cruzi cyclin, putative 0.0664 0.158 0.6788
Loa Loa (eye worm) hypothetical protein 0.0989 0.2435 0.6972
Echinococcus multilocularis cyclin 0.0101 0.0105 0.0105
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0664 0.158 0.6788
Schistosoma mansoni cyclin B3 0.0419 0.094 0.094
Brugia malayi Cyclin, N-terminal domain containing protein 0.0419 0.094 0.269
Trypanosoma cruzi cdc2-related kinase 1 0.0215 0.0403 0.1374
Echinococcus granulosus mitogen activated protein kinase 14 0.093 0.2279 0.2279
Echinococcus granulosus mitogen activated protein kinase 11 0.093 0.2279 0.2279
Trypanosoma brucei mitotic cyclin 6 0.0664 0.158 0.6788
Echinococcus multilocularis cyclin dependent kinase 5 0.0215 0.0403 0.0403
Toxoplasma gondii hypothetical protein 0.0318 0.0674 1
Trichomonas vaginalis cyclins, putative 0.0664 0.158 0.4355
Trichomonas vaginalis cyclins, putative 0.0664 0.158 0.4355
Brugia malayi Immunoglobulin I-set domain containing protein 0.0067 0.0015 0.0042
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.093 0.2279 0.6523
Echinococcus multilocularis cyclins 0.0419 0.094 0.094
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Echinococcus multilocularis cyclin dependent kinase 1 0.0215 0.0403 0.0403
Echinococcus multilocularis cyclin dependent kinase 0.0215 0.0403 0.0403
Trichomonas vaginalis cyclin B, putative 0.0664 0.158 0.4355
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Trichomonas vaginalis cyclin A, putative 0.0664 0.158 0.4355
Echinococcus granulosus twitchin 0.0108 0.0122 0.0122
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0215 0.0403 0.5246
Entamoeba histolytica cell division protein kinase 2, putative 0.0215 0.0403 0.0881
Echinococcus granulosus cyclins 0.0419 0.094 0.094
Echinococcus multilocularis cyclin G2 0.0101 0.0105 0.0105
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Echinococcus multilocularis cyclin G2 0.0101 0.0105 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.0403 0.0881
Giardia lamblia Cyclin A 0.0419 0.094 0.5657
Loa Loa (eye worm) cyclin domain-containing protein 0.0101 0.0105 0.03
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0215 0.0403 0.0403
Brugia malayi Cyclin, N-terminal domain containing protein 0.0101 0.0105 0.03
Loa Loa (eye worm) hypothetical protein 0.0664 0.158 0.4524
Trichomonas vaginalis AGC family protein kinase 0.1393 0.3493 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0215 0.0403 0.0403
Echinococcus granulosus cyclin dependent kinase 1 0.0215 0.0403 0.0403
Brugia malayi Protein kinase domain containing protein 0.1393 0.3493 1
Trichomonas vaginalis cyclins, putative 0.0664 0.158 0.4355
Echinococcus multilocularis cyclin b3 0.0419 0.094 0.094
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0215 0.0403 0.1155
Plasmodium falciparum cyclin 0.0419 0.094 1
Brugia malayi Cyclin C 0.0101 0.0105 0.03
Echinococcus multilocularis mitogen activated protein kinase 14 0.093 0.2279 0.2279
Brugia malayi Cyclin, N-terminal domain containing protein 0.0664 0.158 0.4524
Echinococcus multilocularis cyclin dependent kinase 6 0.3873 1 1
Echinococcus multilocularis cyclin y 0.0101 0.0105 0.0105
Loa Loa (eye worm) cyclin C 0.0101 0.0105 0.03

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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