Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | agrin | 0.0322 | 0.02 | 0.0521 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0461 | 0.04 | 0.9335 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0322 | 0.02 | 0.02 |
Onchocerca volvulus | 0.0472 | 0.0415 | 0.0219 | |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0472 | 0.0415 | 0.0415 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0322 | 0.02 | 0.02 |
Brugia malayi | hypothetical protein | 0.0472 | 0.0415 | 0.0415 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Onchocerca volvulus | 0.0472 | 0.0415 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0472 | 0.0415 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0472 | 0.0415 | 0.0219 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0461 | 0.04 | 0.9335 |
Onchocerca volvulus | 0.0472 | 0.0415 | 0.0219 | |
Echinococcus granulosus | follistatin | 0.0322 | 0.02 | 0.0521 |
Loa Loa (eye worm) | glutamate receptor | 0.0375 | 0.0276 | 0.0077 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0472 | 0.0415 | 0.0219 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0426 | 0.035 | 0.8419 |
Schistosoma mansoni | organic anion transporter | 0.0472 | 0.0415 | 1 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0472 | 0.0415 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.7147 | 1 | 1 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0472 | 0.0415 | 1 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0472 | 0.0415 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0322 | 0.02 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Onchocerca volvulus | 0.0472 | 0.0415 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0314 | 0.0189 | 0.4539 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0472 | 0.0415 | 0.0415 |
Echinococcus granulosus | agrin | 0.0322 | 0.02 | 0.0521 |
Echinococcus multilocularis | follistatin | 0.0322 | 0.02 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.0415 | 0.0219 |
Schistosoma mansoni | follistatin | 0.0322 | 0.02 | 0.4824 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0472 | 0.0415 | 0.0415 |
Schistosoma mansoni | agrin | 0.0322 | 0.02 | 0.4824 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.034 | 0.0225 | 0.0225 |
Schistosoma mansoni | organic anion transporter | 0.0472 | 0.0415 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0472 | 0.0415 | 0.0219 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0322 | 0.02 | 0.02 |
Echinococcus multilocularis | expressed protein | 0.0322 | 0.02 | 0.0521 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0472 | 0.0415 | 1 |
Brugia malayi | hypothetical protein | 0.0472 | 0.0415 | 0.0415 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0375 | 0.0276 | 0.0276 |
Onchocerca volvulus | 0.0472 | 0.0415 | 0.0219 | |
Trypanosoma cruzi | MFS transporter, putative | 0.0472 | 0.0415 | 0.5 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.0322 | 0.02 | 0.02 |
Brugia malayi | SPARC precursor | 0.0322 | 0.02 | 0.02 |
Onchocerca volvulus | Putative organic anion transporter | 0.7147 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0461 | 0.04 | 0.0204 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 196 nM | Displacement of [3H]histamine from recombinant human histamine H4 receptor | ChEMBL. | 21920744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.