Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan IH, family I25, phytocystatin-like peptidase inhibitor | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | cystatin | 0.0034 | 0.5 | 0.5 |
Echinococcus multilocularis | Cystatin B (Stefin B) | 0.0034 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 | |
Echinococcus granulosus | Cystatin B Stefin B | 0.0034 | 0.5 | 0.5 |
Brugia malayi | cystatin-type cysteine proteinase inhibitor CPI-2, putative | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | cystatin-type cysteine proteinase inhibitor CPI-1 | 0.0034 | 0.5 | 0.5 |
Schistosoma mansoni | cystatin B | 0.0034 | 0.5 | 0.5 |
Echinococcus multilocularis | proteinase inhibitor I25, cystatin | 0.0034 | 0.5 | 0.5 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | cysteine protease inhibitor | 0.0034 | 0.5 | 0.5 |
Brugia malayi | cystatin | 0.0034 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 | |
Echinococcus granulosus | proteinase inhibitor I25 cystatin | 0.0034 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0034 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 32 nM | Antagonist activity at human recombinant MCHR1 expressed in CHO-K1 cells assessed as inhibition of MCH-induced IP3 accumulation response preincubated for 10 mins prior MCH peptide-stimulation measured after 45 mins by IP3-SPA-YSI assay | ChEMBL. | 22497763 |
IC50 (binding) | = 54 nM | Displacement of [125-I]MCH from human recombinant MCHR1 expressed in CHO-K1 cell membranes after 2 hrs by scintillation proximity assay | ChEMBL. | 22497763 |
Inhibition (binding) | = 39 % | Inhibition of human ERG expressed in HEK293 cells at 1 uM by voltage clamp electrophysiology assay | ChEMBL. | 22497763 |
Inhibition (binding) | = 79 % | Inhibition of human ERG expressed in HEK293 cells at 3 uM by voltage clamp electrophysiology assay | ChEMBL. | 22497763 |
Stability (ADMET) | = 58 % | Metabolic stability in mouse liver microsomes assessed as compound remaining at 30 mins | ChEMBL. | 22497763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.