Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Mus musculus | bombesin-like receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 375 aa | 21.1 % |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | bombesin-like receptor 3 | 399 aa | 380 aa | 20.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neuroglian | 0.004 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0029 | 0.0702 |
Echinococcus granulosus | roundabout 2 | 0.005 | 0.0039 | 0.0039 |
Echinococcus granulosus | defective proboscis extension response | 0.0032 | 0.0016 | 0.0016 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0356 | 0.0416 | 1 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.8124 | 1 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0032 | 0.0016 | 0.0016 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0032 | 0.0016 | 0.0016 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0032 | 0.0016 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Schistosoma mansoni | vesicular amine transporter | 0.0032 | 0.0016 | 0.0016 |
Schistosoma mansoni | cell adhesion molecule | 0.0042 | 0.0029 | 0.0029 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0322 | 0.0374 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0032 | 0.0016 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0039 | 0.0943 |
Schistosoma mansoni | nephrin | 0.004 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0039 | 0.0943 |
Echinococcus multilocularis | neuroglian | 0.004 | 0.0026 | 0.0026 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.8124 | 1 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.005 | 0.0039 | 0.0039 |
Echinococcus multilocularis | Immunoglobulin | 0.0032 | 0.0016 | 0.0016 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.8124 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0032 | 0.0016 | 0.0016 |
Echinococcus granulosus | Immunoglobulin | 0.0032 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0356 | 0.0416 | 1 |
Onchocerca volvulus | 0.0311 | 0.0361 | 0.9637 | |
Brugia malayi | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Schistosoma mansoni | tyrosine kinase | 0.0021 | 0.0004 | 0.0004 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0042 | 0.0029 | 0.0029 |
Toxoplasma gondii | MAPEG family protein | 0.8124 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Echinococcus multilocularis | Immunoglobulin | 0.0032 | 0.0016 | 0.0016 |
Echinococcus granulosus | twitchin | 0.004 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0016 | 0.0395 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 17 % | Activation of PXR at 10 uM | ChEMBL. | 24900461 |
Activity (functional) | = 105 % | Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay relative to dY-peptide | ChEMBL. | 22494842 |
Activity (functional) | = 106 % | Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay relative to dY-peptide | ChEMBL. | 22494842 |
Activity (functional) | = 106 % | Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay relative to dY-peptide | ChEMBL. | 24900461 |
Activity (functional) | = 5.6 degreeC.hr | Increase of core body temperature in DIO mouse assessed as AUC (1 to 6 hrs) of body temperature changes at 3 mg/kg by fasted temperature PD assay | ChEMBL. | 24900461 |
EC50 (binding) | = 1.4 nM | Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | ChEMBL. | 24412111 |
EC50 (binding) | = 22 nM | Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay | ChEMBL. | 24412111 |
EC50 (functional) | = 73 nM | Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay | ChEMBL. | 22494842 |
EC50 (binding) | = 73 nM | Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay | ChEMBL. | 25497965 |
EC50 (functional) | = 130 nM | Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay | ChEMBL. | 22494842 |
EC50 (functional) | = 130 nM | Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay | ChEMBL. | 24900461 |
EC50 (binding) | = 130 nM | Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay | ChEMBL. | 25497965 |
EC50 (binding) | > 30 uM | Activation of PXR | ChEMBL. | 24900461 |
IC50 (binding) | = 3.6 nM | Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting | ChEMBL. | 22494842 |
IC50 (binding) | = 3.6 nM | Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting | ChEMBL. | 24900461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.