Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0702 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0702 | 1 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0702 | 1 | 0.5 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0702 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.045 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0484 | 0.1351 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0484 | 0.1351 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0702 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC170 (functional) | = 4.27 uM | Upregulation of ApoA1 expression in human HepG2 cells assessed as concentration required to increase 70% of luciferase activity after 18 hrs by luciferase reporter gene assay | ChEMBL. | 22386529 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.