Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Sigma opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0093 | 0.1214 | 0.5363 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0093 | 0.1214 | 0.2737 |
Echinococcus granulosus | nervana 2 | 0.0082 | 0.0949 | 0.2141 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0222 | 0.4435 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0085 | 0.1008 | 0.2273 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 1 | 1 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0127 | 0.2057 | 0.2057 |
Giardia lamblia | Kinase, TTK | 0.0222 | 0.4435 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0093 | 0.1214 | 0.2737 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0222 | 0.4435 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0093 | 0.1214 | 0.2737 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0135 | 0.2263 | 0.2263 |
Echinococcus multilocularis | nervana 2 | 0.0082 | 0.0949 | 0.2141 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 1 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0085 | 0.1008 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0085 | 0.1008 | 0.2273 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0082 | 0.0949 | 0.2141 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0093 | 0.1214 | 0.5363 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0222 | 0.4435 | 1 |
Loa Loa (eye worm) | TTK protein kinase | 0.0222 | 0.4435 | 0.4435 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0222 | 0.4435 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Echinococcus granulosus | nervana 2 | 0.0082 | 0.0949 | 0.2141 |
Toxoplasma gondii | AGC kinase | 0.0127 | 0.2057 | 0.5 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0093 | 0.1214 | 0.2737 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0082 | 0.0949 | 0.2141 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0093 | 0.1214 | 0.0229 |
Trypanosoma cruzi | Protein kinase B | 0.0093 | 0.1214 | 0.0229 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0127 | 0.2057 | 0.2057 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0.2263 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0135 | 0.2263 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0082 | 0.0949 | 0.2141 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0085 | 0.1008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.4569 | 0.4569 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Brugia malayi | Protein kinase domain containing protein | 0.0135 | 0.2263 | 0.2263 |
Entamoeba histolytica | protein kinase, putative | 0.0127 | 0.2057 | 0.909 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0082 | 0.0949 | 0.2141 |
Entamoeba histolytica | protein kinase 2, putative | 0.0085 | 0.1008 | 0.4453 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0085 | 0.1008 | 0.2273 |
Brugia malayi | Protein kinase domain containing protein | 0.0222 | 0.4435 | 0.4435 |
Echinococcus multilocularis | nervana 2 | 0.0082 | 0.0949 | 0.2141 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0222 | 0.4435 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Trichomonas vaginalis | AGC family protein kinase | 0.0053 | 0.0206 | 0.0464 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 1 | 0.5 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0222 | 0.4435 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.2263 | 0.5104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 30.3 nM | Displacement of [3H]-pentazocine from sigma 1 opioid receptor in rat liver homogenate by liquid scintillation counting | ChEMBL. | 24900272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.