Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0215 | 0.0298 | 0.0161 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0336 | 0.0242 |
Echinococcus multilocularis | presenilin | 0.0215 | 0.0298 | 0.0298 |
Brugia malayi | Presenilin family protein | 0.0215 | 0.0298 | 0.0203 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0202 | 0.0279 | 0.0184 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Echinococcus multilocularis | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0202 | 0.0279 | 0.0184 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.0097 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3512 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3512 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0215 | 0.0298 | 1 |
Schistosoma mansoni | Protein orai-1 | 0.6958 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Echinococcus granulosus | nicalin | 0.0039 | 0.0044 | 0.0044 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Schistosoma mansoni | Protein orai-1 | 0.6958 | 1 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Echinococcus granulosus | presenilin | 0.0215 | 0.0298 | 0.0298 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6958 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Echinococcus granulosus | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2493 | 0.3575 | 0.3575 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0215 | 0.0298 | 1 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6958 | 1 | 1 |
Echinococcus multilocularis | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0202 | 0.0279 | 0.0279 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3484 |
Loa Loa (eye worm) | hypothetical protein | 0.6958 | 1 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0202 | 0.0279 | 0.0279 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2493 | 0.3575 | 0.3575 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0061 | 0.0076 | 0.0239 |
Echinococcus multilocularis | nicalin | 0.0039 | 0.0044 | 0.0044 |
Brugia malayi | olfactory channel protein osm-9 | 0.0242 | 0.0336 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2.5 ug ml-1 | In vitro antibacterial activity against S. aureus 011HT3 | ChEMBL. | 10522710 |
MIC (functional) | = 2.5 ug ml-1 | In vitro antibacterial activity against S. epidermidis 012GO39 OxaTei-R | ChEMBL. | 10522710 |
MIC (functional) | = 5 ug ml-1 | In vitro antibacterial activity against S. aureus 011GO76 OfloOxaEry-R | ChEMBL. | 10522710 |
MIC (functional) | = 10 ug ml-1 | In vitro antibacterial activity against S. pyogenes O2A1UC1 | ChEMBL. | 10522710 |
MIC (functional) | = 40 ug ml-1 | In vitro antibacterial activity against S. aureus 011HT1 Nov-R | ChEMBL. | 10522710 |
MIC (functional) | > 40 ug ml-1 | In vitro antibacterial activity against E. faecium 02D31P2 VanTeiEry-R | ChEMBL. | 10522710 |
Ratio (binding) | = 0.57 | In vitro inhibition of supercoiling activity of E. coli DNA gyrase as the ratio of IC50 of Novobiocin and IC50 of compound | ChEMBL. | 10522710 |
Ratio (binding) | = 0.57 | In vitro inhibition of supercoiling activity of E. coli DNA gyrase as the ratio of IC50 of Novobiocin and IC50 of compound | ChEMBL. | 10522710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.