Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone deacetylase 4 5 | 0.033 | 0.8729 | 0.6371 |
Plasmodium vivax | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Trypanosoma brucei | histone deacetylase 3 | 0.033 | 0.8729 | 1 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.033 | 0.8729 | 1 |
Leishmania major | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0306 | 0.7207 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0306 | 0.7207 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0306 | 0.7207 | 0.2028 |
Brugia malayi | Histone deacetylase family protein | 0.033 | 0.8729 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.033 | 0.8729 | 0.6371 |
Echinococcus multilocularis | histone deacetylase | 0.033 | 0.8729 | 0.6371 |
Trypanosoma brucei | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0306 | 0.7207 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.033 | 0.8729 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1271 | 0.1456 |
Plasmodium falciparum | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0294 | 0.6497 | 0.7443 |
Plasmodium vivax | histone deacetylase 2, putative | 0.033 | 0.8729 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.033 | 0.8729 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0306 | 0.7207 | 0.8257 |
Echinococcus granulosus | histone deacetylase | 0.033 | 0.8729 | 0.6371 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.033 | 0.8729 | 0.6371 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.6497 | 0.7443 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0351 | 1 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0306 | 0.7207 | 0.2028 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0351 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Echinococcus granulosus | histone deacetylase 7 | 0.033 | 0.8729 | 0.6371 |
Brugia malayi | Protein kinase domain containing protein | 0.0306 | 0.7207 | 0.3182 |
Loa Loa (eye worm) | histone deacetylase | 0.033 | 0.8729 | 1 |
Leishmania major | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.033 | 0.8729 | 0.6371 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0306 | 0.7207 | 0.2028 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0306 | 0.7207 | 0.8257 |
Echinococcus granulosus | histone deacetylase 6 | 0.033 | 0.8729 | 0.6371 |
Brugia malayi | Histone deacetylase family protein | 0.033 | 0.8729 | 1 |
Giardia lamblia | Histone deacetylase | 0.0294 | 0.6497 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.033 | 0.8729 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.033 | 0.8729 | 0.6371 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.033 | 0.8729 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0306 | 0.7207 | 1 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0306 | 0.7207 | 0.3182 |
Echinococcus multilocularis | histone deacetylase 7 | 0.033 | 0.8729 | 0.6371 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0294 | 0.6497 | 0.7443 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.631 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.571 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.544 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.488 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.433 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.397 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.367 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.206 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.121 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.