Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone deacetylase 7 | 0.0113 | 0.6079 | 0.2838 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0113 | 0.6079 | 0.2838 |
Leishmania major | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0145 | 1 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0113 | 0.6079 | 0.2838 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0113 | 0.6079 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0113 | 0.6079 | 1 |
Leishmania major | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0145 | 1 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0101 | 0.4524 | 0.4524 |
Echinococcus multilocularis | histone deacetylase 6 | 0.012 | 0.6964 | 0.4455 |
Echinococcus granulosus | histone deacetylase | 0.0113 | 0.6079 | 0.2838 |
Echinococcus granulosus | histone deacetylase 6 | 0.0113 | 0.6079 | 0.2838 |
Echinococcus granulosus | histone deacetylase 7 | 0.0113 | 0.6079 | 0.2838 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0113 | 0.6079 | 0.2838 |
Brugia malayi | Histone deacetylase family protein | 0.0113 | 0.6079 | 0.2838 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0101 | 0.4524 | 0.4524 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4524 | 0.4524 |
Trypanosoma brucei | histone deacetylase 3 | 0.0113 | 0.6079 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0145 | 1 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0145 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0113 | 0.6079 | 0.2838 |
Echinococcus granulosus | histone deacetylase 6 | 0.0113 | 0.6079 | 0.2838 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0113 | 0.6079 | 0.6079 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0145 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 4 | 0.0113 | 0.6079 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0113 | 0.6079 | 0.6079 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0113 | 0.6079 | 0.2838 |
Schistosoma mansoni | histone deacetylase hda2 | 0.012 | 0.6964 | 0.4455 |
Trichomonas vaginalis | AGC family protein kinase | 0.0145 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0101 | 0.4524 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0145 | 1 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0113 | 0.6079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0885 | 0.0885 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0113 | 0.6079 | 0.2838 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0113 | 0.6079 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0145 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0145 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.012 | 0.6964 | 0.4455 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.526 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.871 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.84 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.629 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.621 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.616 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.604 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.585 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.546 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.