Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0217 | 0.0079 | 0.0079 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0456 | 0.1285 | 0.1216 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2181 | 1 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0217 | 0.0079 | 0.0079 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0943 | 0.3745 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0217 | 0.0079 | 0.0079 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0943 | 0.3745 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0217 | 0.0079 | 0.0079 |
Echinococcus multilocularis | glycogen phosphorylase | 0.2181 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.2181 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | nuclear receptor NHR-88 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | steroid hormone receptor | 0.0217 | 0.0079 | 0.0079 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.2181 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.2181 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.2181 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.2181 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0217 | 0.0079 | 0.0079 |
Giardia lamblia | Glycogen phosphorylase | 0.2181 | 1 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.2181 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.2181 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0217 | 0.0079 | 0.0079 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.2181 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0217 | 0.0079 | 0.0079 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.2181 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0943 | 0.3745 | 0.3696 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0217 | 0.0079 | 0.0079 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.2181 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0217 | 0.0079 | 0.0079 |
Schistosoma mansoni | glycogen phosphorylase | 0.2181 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0217 | 0.0079 | 0.0079 |
Brugia malayi | nuclear hormone receptor | 0.0217 | 0.0079 | 0.0079 |
Echinococcus granulosus | glycogen phosphorylase | 0.2181 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.379 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.066 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.956 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.673 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.508 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.497 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.412 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.377 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.31 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.