Detailed information for compound 1647657

Basic information

Technical information
  • TDR Targets ID: 1647657
  • Name: (2E,4E)-5-(4-dimethylaminophenyl)-2-phenylpen ta-2,4-dienenitrile
  • MW: 274.36 | Formula: C19H18N2
  • H donors: 0 H acceptors: 1 LogP: 4.47 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/C=C/c1ccc(cc1)N(C)C)/c1ccccc1
  • InChi: 1S/C19H18N2/c1-21(2)19-13-11-16(12-14-19)7-6-10-18(15-20)17-8-4-3-5-9-17/h3-14H,1-2H3/b7-6+,18-10-
  • InChiKey: PZOBYPZHMFNXCV-WNQIWMROSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E,4E)-5-(4-dimethylaminophenyl)-2-phenyl-penta-2,4-dienenitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0056 0.0956 1
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0225 0.0308
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0056 0.0956 0.0933
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0427 0.2021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0046 0.0735 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.1313
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0225 0.0201
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0059 0.1025 0.4848
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.1313
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0533 0.051
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0412 0.2557
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0025 0.0116
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.1313
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0428 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.2066
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0428 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0437 0.2066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0158 0.075
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0437 0.2066
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0427 0.1365
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Entamoeba histolytica protein kinase, putative 0.0033 0.0427 0.2763
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0225 0.5
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0428 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum hexose transporter 0.0107 0.2114 0.2094
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0428 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trypanosoma brucei glucose transporter 1E 0.0033 0.0437 0.4427
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2114 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Entamoeba histolytica cdc48-like protein, putative 0.0056 0.0956 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0225 0.0201
Loa Loa (eye worm) hypothetical protein 0.0024 0.0225 0.0681
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0024 0.0238 0.0722
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3611 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0412 0.1313
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.0735 0.2407
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0225 0.0681
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Mycobacterium tuberculosis Putative conserved ATPase 0.0035 0.0486 1
Brugia malayi Protein kinase domain containing protein 0.0046 0.0735 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Trypanosoma cruzi Valosin-containing protein, putative 0.0056 0.0956 1
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.0735 0.2407
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0428 0.0404
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0059 0.1025 0.339
Leishmania major glucose transporter, lmgt2 0.0033 0.0437 0.4427
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2114 0.7081
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0412 0.1313
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0437 0.4427
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0225 0.0681
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0225 0.4353
Plasmodium vivax cell division cycle ATPase, putative 0.0021 0.0169 0.0144
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) vesicle-fusing ATPase 0.0035 0.047 0.1509
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni hypothetical protein 0.0107 0.2114 0.7081
Echinococcus multilocularis insulin receptor 0.0046 0.0735 0.2407
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0024 0.0238 0.0722
Plasmodium vivax CDK-related protein kinase 6, putative 0.0453 1 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0427 0.1365
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0428 0.0617
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0059 0.1025 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.0735 0.2407
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0078 0.1452 0.4837
Loa Loa (eye worm) TK/EGFR protein kinase 0.0144 0.2975 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0428 0.0404
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0427 0.4324
Trypanosoma cruzi hexose transporter 0.0033 0.0437 0.4427
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0533 0.051
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0428 0.0404
Echinococcus multilocularis General substrate transporter 0.0092 0.1772 0.5923
Brugia malayi Cam kinase protein 1 0.0033 0.0427 0.1365
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0428 0.0404
Toxoplasma gondii cell division protein CDC48AP 0.0035 0.0486 0.0707
Trypanosoma brucei glucose transporter 2A 0.0033 0.0437 0.4427
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0437 0.2066
Loa Loa (eye worm) hypothetical protein 0.0033 0.0427 0.1365
Leishmania major glucose transporter, lmgt1 0.0033 0.0437 0.4427
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.1452 0.4837
Schistosoma mansoni tyrosine kinase 0.0046 0.0735 0.2407
Leishmania major glucose transporter, lmgt3 0.0033 0.0437 0.4427
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0225 0.0681
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) VCP protein 0.0024 0.0238 0.0722
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Loa Loa (eye worm) sugar transporter 0.0107 0.2114 0.7081
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.1452 0.4837
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0144 0.258
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.1313
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0025 0.0116
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.1452 0.4837
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0225 0.1066
Brugia malayi vesicle-fusing ATPase 0.0035 0.047 0.1509
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0144 0.258
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0428 0.0617
Schistosoma mansoni protein kinase 0.0033 0.0427 0.1365
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0437 0.4427
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0225 0.0681
Trypanosoma brucei Valosin-containing protein 0.0056 0.0956 1
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0427 0.1365
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0059 0.1025 0.339
Entamoeba histolytica protein kinase, putative 0.0033 0.0427 0.2763
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0056 0.0956 0.3156
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3611 0.5495
Schistosoma mansoni glucose transport protein 0.0107 0.2114 0.7081
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0412 0.1313
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0427 0.1365
Echinococcus multilocularis epidermal growth factor receptor 0.0144 0.2975 1
Toxoplasma gondii cell division protein CDC48CY 0.0059 0.1025 0.1532
Brugia malayi Sugar transporter family protein 0.0107 0.2114 0.7081
Giardia lamblia AAA family ATPase 0.0035 0.0486 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0225 0.2157
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0427 0.1365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0275 0.085
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0412 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0412 0.195
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Loa Loa (eye worm) hypothetical protein 0.0035 0.047 0.1509
Brugia malayi valosin containing protein 0.0035 0.047 0.1509
Leishmania major protein kinase, putative 0.0033 0.0427 0.4324
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Plasmodium falciparum protein kinase 7 0.0301 0.6551 0.6542
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0533 0.0779
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0024 0.0238 0.0722
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0427 0.1365
Echinococcus multilocularis 0.0045 0.0702 0.2295
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0025 0.5
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0035 0.0486 0.0707
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0225 0.3046
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0412 0.1313
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0428 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0437 0.4427
Schistosoma mansoni tyrosine kinase 0.0078 0.1452 0.4837
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0381 0.1208
Trypanosoma brucei glucose transporter, putative 0.0033 0.0437 0.4427
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0428 0.0617
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2114 0.3201
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0412 0.8401
Echinococcus granulosus insulin receptor 0.0046 0.0735 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0056 0.0956 0.0933
Brugia malayi Furin-like cysteine rich region family protein 0.0144 0.2975 1
Toxoplasma gondii protein kinase, putative 0.0301 0.6551 1
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0056 0.0956 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0437 0.2066
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3611 0.3595
Mycobacterium ulcerans ATPase 0.0035 0.0486 1
Echinococcus granulosus General substrate transporter 0.0092 0.1772 0.5923
Schistosoma mansoni tyrosine kinase 0.0077 0.1433 0.4774
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0025 0.0116
Echinococcus granulosus epidermal growth factor receptor 0.0144 0.2975 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0059 0.1025 0.339
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0533 0.546
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0095 0.0755
Schistosoma mansoni tyrosine kinase 0.0144 0.2975 1
Plasmodium vivax hexose transporter 0.0107 0.2114 0.2094
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2114 0.7081
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0381 0.1208
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0225 0.0681

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.713 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.562 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.855 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.838 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.785 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.464 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.433 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.343 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.337 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.254 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.104 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.