Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cell division cycle 7 | Starlite/ChEMBL | No references |
Homo sapiens | neurotrophic tyrosine kinase, receptor, type 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0069 | 1 | 1 | |
Entamoeba histolytica | protein kinase domain containing protein | 0.0002 | 0 | 0.5 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0058 | 0.8369 | 1 |
Giardia lamblia | Kinase, CDC7 | 0.0069 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.8369 | 0.8369 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.8369 | 0.8369 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0002 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0058 | 0.8369 | 0.8369 |
Schistosoma mansoni | polycystin 1-related | 0.0058 | 0.8369 | 0.8369 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0058 | 0.8369 | 0.8369 |
Onchocerca volvulus | 0.0069 | 1 | 1 | |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0058 | 0.8369 | 0.8369 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0058 | 0.8369 | 0.8369 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0058 | 0.8369 | 0.5 |
Toxoplasma gondii | calcium dependent protein kinase CDPK8 | 0.0002 | 0 | 0.5 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0069 | 1 | 1 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0069 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0069 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.0002 | 0 | 0.5 |
Echinococcus multilocularis | RUN | 0.0058 | 0.8369 | 0.8369 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0058 | 0.8369 | 0.8369 |
Trypanosoma brucei | STE/STE11 serine/threonine-protein kinase, putative | 0.0002 | 0 | 0.5 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0069 | 1 | 1 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0058 | 0.8369 | 0.8369 |
Schistosoma mansoni | rab6-interacting | 0.0058 | 0.8369 | 0.8369 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0058 | 0.8369 | 0.8369 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0002 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 1 | 1 |
Echinococcus granulosus | RUN | 0.0058 | 0.8369 | 0.8369 |
Schistosoma mansoni | rab6-interacting | 0.0058 | 0.8369 | 0.8369 |
Trypanosoma brucei | protein kinase, putative | 0.0002 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (functional) | = 5.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: NTRK1 | ChEMBL. | No reference |
Ki (functional) | = 7 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.