Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pantothenate kinase | 0.1349 | 1 | 1 |
Echinococcus granulosus | pantothenate kinase 4 | 0.1349 | 1 | 1 |
Leishmania major | pantothenate kinase subunit, putative | 0.1349 | 1 | 0.5 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Toxoplasma gondii | fumble protein | 0.1349 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0623 | 0.0623 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.1349 | 1 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.1349 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Giardia lamblia | Pantothenate kinase 4 | 0.1349 | 1 | 0.5 |
Onchocerca volvulus | Fumble homolog | 0.1349 | 1 | 0.5 |
Loa Loa (eye worm) | pantothenate kinase | 0.1349 | 1 | 1 |
Plasmodium vivax | pantothenate kinase, putative | 0.1349 | 1 | 1 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.1349 | 1 | 0.5 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.1349 | 1 | 0.5 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.1349 | 1 | 1 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.1349 | 1 | 0.5 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.1349 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.465 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.327 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.261 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.201 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.889 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.819 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.539 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.246 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.233 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.