Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0262 | 0.2928 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0139 | 0.0155 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0139 | 0.0155 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0285 | 0.2268 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0262 | 0.2928 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0139 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0262 | 0.2928 |
Schistosoma mansoni | o-methyltransferase | 0.0124 | 0.0894 | 1 |
Mycobacterium tuberculosis | Probable methyltransferase | 0.0124 | 0.0894 | 0.1 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0139 | 0.1553 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0139 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0139 | 0.0612 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0139 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0285 | 0.2268 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0139 | 0.1553 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Brugia malayi | O-methyltransferase | 0.0124 | 0.0894 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0139 | 0.1026 | 0.1147 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0139 | 0.1026 | 0.1026 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0139 | 1 |
Mycobacterium leprae | PROBABLE METHYLTRANSFERASE | 0.0124 | 0.0894 | 0.8513 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.1026 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0139 | 0.1553 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0139 | 0.0612 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0139 | 0.0139 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Onchocerca volvulus | 0.0124 | 0.0894 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0128 | 0.1434 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0139 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0139 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0139 | 0.0612 |
Schistosoma mansoni | o-methyltransferase | 0.0124 | 0.0894 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0139 | 0.0155 |
Onchocerca volvulus | 0.0124 | 0.0894 | 1 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Wolbachia endosymbiont of Brugia malayi | O-methyltransferase | 0.0124 | 0.0894 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0139 | 0.0139 |
Schistosoma mansoni | o-methyltransferase | 0.0124 | 0.0894 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Loa Loa (eye worm) | O-methyltransferase | 0.0124 | 0.0894 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0139 | 0.1553 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0139 | 0.0155 |
Brugia malayi | O-methyltransferase family protein | 0.0124 | 0.0894 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0139 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0894 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0139 | 0.0155 |
Schistosoma mansoni | o-methyltransferase | 0.0124 | 0.0894 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0139 | 0.0139 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0139 | 0.0155 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0139 | 0.0155 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0139 | 0.0139 |
Mycobacterium tuberculosis | Probable catechol-O-methyltransferase | 0.107 | 0.8945 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0139 | 0.1553 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0139 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0139 | 0.0139 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0139 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0139 | 0.0155 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0139 | 0.0155 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.1751 | 0.1958 |
Brugia malayi | O-methyltransferase family protein | 0.0124 | 0.0894 | 1 |
Mycobacterium ulcerans | methyltransferase | 0.0124 | 0.0894 | 0.0894 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0139 | 0.1553 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0139 | 0.1553 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0139 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0262 | 0.2928 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0285 | 0.2268 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0128 | 0.1434 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0128 | 0.1434 |
Brugia malayi | O-methyltransferase family protein | 0.0124 | 0.0894 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0139 | 0.0612 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0139 | 0.0612 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0139 | 0.0612 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0139 | 0.1553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.628 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.