TDR Targets

Basic information

Technical information

TDR Targets ID: 1650963
Name: [(6R,7S,8R,9S)-8,9-diacetyloxy-6-(acetyloxyme thyl)-6,7,8,9-tetrahydrotetrazolo[1,5-b]oxaze pin-7-yl] acetate
MW: 386.314 | Formula: C14H18N4O9
H donors: 0 H acceptors: 7 LogP: -0.63 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OC[C@H]1On2nnnc2[C@@H]([C@H]([C@@H]1OC(=O)C)OC(=O)C)OC(=O)C
InChi: 1S/C14H18N4O9/c1-6(19)23-5-10-11(24-7(2)20)12(25-8(3)21)13(26-9(4)22)14-15-16-17-18(14)27-10/h10-13H,5H2,1-4H3/t10-,11-,12+,13-/m1/s1
InChiKey: PFRTWZMTMWCXRK-FVCCEPFGSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

[(6R,7S,8R,9S)-8,9-diacetoxy-6-(acetoxymethyl)-6,7,8,9-tetrahydrotetrazolo[1,5-b]oxazepin-7-yl] acetate
acetic acid [(6R,7S,8R,9S)-8,9-diacetoxy-6-(acetoxymethyl)-6,7,8,9-tetrahydrotetrazolo[1,5-b]oxazepin-7-yl] ester
[(6R,7S,8R,9S)-8,9-diacetyloxy-6-(acetyloxymethyl)-6,7,8,9-tetrahydro-[1,2,3,4]tetrazolo[1,5-b][1,2]oxazepin-7-yl] ethanoate
NCI60_026782

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	geminin	0.0336	0.8961	0.9232
Echinococcus multilocularis	sex peptide receptor	0.0024	0.0132	0.0068
Trypanosoma brucei	DNA polymerase IV, putative	0.0028	0.0246	0.0466
Brugia malayi	ImpB/MucB/SamB family protein	0.0028	0.0246	0.018
Entamoeba histolytica	glycogen phosphorylase, putative	0.0099	0.2253	0.3532
Giardia lamblia	Glycogen phosphorylase	0.0229	0.5929	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0132	0.0073
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0099	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	ImpB/MucB/SamB family protein	0.0028	0.0246	0.018
Echinococcus granulosus	somatostatin receptor	0.0024	0.0132	0.0068
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0041	0.0621	0.0743
Brugia malayi	RE15519p	0.0024	0.0132	0.0066
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0024	0.0132	0.0068
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	amine GPCR	0.0024	0.0132	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Schistosoma mansoni	hypothetical protein	0.0336	0.8961	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0099	0.2253	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0024	0.0132	0.0068
Brugia malayi	G-protein coupled receptor	0.0024	0.0132	0.0066
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0132	0.0068
Trypanosoma brucei	DNA polymerase eta, putative	0.0028	0.0246	0.0466
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0024	0.0132	0.0073
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0063	0.1243	0.1184
Echinococcus granulosus	geminin	0.0336	0.8961	0.9232
Echinococcus granulosus	dna polymerase kappa	0.0028	0.0246	0.0186
Brugia malayi	G-protein coupled receptor	0.0024	0.0132	0.0066
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.2991	0.3287
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0024	0.0132	0.0066
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0132	0.0073
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.007	0.1421	0.1522
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	RNA, U transporter 1	0.0067	0.1357	0.1298
Schistosoma mansoni	amine GPCR	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	serotonin receptor	0.0024	0.0132	0.0068
Schistosoma mansoni	glycogen phosphorylase	0.0229	0.5929	0.6591
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.161	0.1602
Brugia malayi	Importin beta-1 subunit	0.0024	0.0123	0.0056
Trypanosoma brucei	DNA polymerase IV, putative	0.0028	0.0246	0.0466
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Schistosoma mansoni	adenoreceptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0123	0.0056
Brugia malayi	Dopamine receptor protein 2	0.0024	0.0132	0.0066
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.0716	0.2342
Echinococcus granulosus	neuropeptide receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.007	0.1421	0.1405
Schistosoma mansoni	myosin xvIII	0.0024	0.0132	0.0073
Echinococcus multilocularis	neuropeptide receptor A26	0.0362	0.9701	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	cathepsin b	0.0125	0.2991	0.3035
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	carbonic anhydrase	0.0063	0.1243	0.1221
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0132	0.0068
Entamoeba histolytica	glycogen phosphorylase, putative	0.0229	0.5929	1
Echinococcus multilocularis	dna polymerase eta	0.0028	0.0246	0.0186
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	dro:myosuppressin receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1243	0.1184
Echinococcus granulosus	glycogen phosphorylase	0.0229	0.5929	0.6085
Schistosoma mansoni	carbonic anhydrase-related	0.0063	0.1243	0.1323
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0272	0.714	0.7341
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0132	0.0066
Brugia malayi	cathepsin B-like cysteine proteinase	0.0125	0.2991	0.2943
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	follicle stimulating hormone receptor	0.0024	0.0132	0.0066
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0132	0.0068
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.007	0.1421	0.1363
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0132	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Schistosoma mansoni	importin beta-1	0.0024	0.0123	0.0063
Echinococcus granulosus	7tm_1 domain containing protein	0.0024	0.0132	0.0068
Toxoplasma gondii	aldehyde dehydrogenase	0.0045	0.0716	0.5297
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0024	0.0132	0.0068
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0045	0.0716	0.0933
Schistosoma mansoni	opsin-like receptor	0.0024	0.0132	0.0073
Brugia malayi	larval opioid receptor	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0076	0.161	0.1554
Echinococcus multilocularis	neuropeptide Y receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0132	0.0068
Entamoeba histolytica	glycogen phosphorylase, putative	0.0099	0.2253	0.3532
Entamoeba histolytica	hypothetical protein	0.0035	0.0441	0.0342
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0253	0.6599	0.6576
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Giardia lamblia	Cathepsin B precursor	0.0041	0.0621	0.0659
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.0716	0.2342
Echinococcus multilocularis	G protein coupled receptor 139	0.0024	0.0132	0.0068
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0125	0.2991	0.5447
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Entamoeba histolytica	glycogenphosphorylase, putative	0.0099	0.2253	0.3532
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	carbonic anhydrase	0.0063	0.1243	0.1221
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1243	0.1184
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Schistosoma mansoni	hypothetical protein	0.0336	0.8961	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0206	0.5285	0.5867
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0206	0.5285	0.5253
Brugia malayi	Serotonin receptor	0.0024	0.0132	0.0066
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	7TM GPCR rhodopsin	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0373	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.007	0.1421	0.1522
Echinococcus granulosus	carbonic anhydrase	0.0063	0.1243	0.1221
Brugia malayi	sulfakinin receptor protein	0.0373	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	TYRA-2 protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	dna polymerase kappa	0.0028	0.0246	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	fmrfamide receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0132	0.0073
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0024	0.0132	0.0073
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0028	0.0246	0.0201
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0441	0.0388
Schistosoma mansoni	hypothetical protein	0.0024	0.0132	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0024	0.0132	0.0066
Loa Loa (eye worm)	glycogen phosphorylase	0.0229	0.5929	0.5902
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0024	0.0132	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Entamoeba histolytica	hypothetical protein	0.0035	0.0441	0.0342
Echinococcus granulosus	orexin receptor type 2	0.0024	0.0132	0.0068
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0132	0.0068
Schistosoma mansoni	glycogen phosphorylase	0.0229	0.5929	0.6591
Brugia malayi	Melatonin receptor type 1A	0.0024	0.0132	0.0066
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0024	0.0132	0.0068
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2991	0.2943
Echinococcus granulosus	carbonic anhydrase	0.0063	0.1243	0.1221
Echinococcus multilocularis	importin subunit beta 1	0.0024	0.0123	0.0058
Echinococcus granulosus	serotonin receptor	0.0024	0.0132	0.0068
Brugia malayi	Serotonin receptor	0.0024	0.0132	0.0066
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0041	0.0621	0.1174
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0441	0.0388
Echinococcus granulosus	g-protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	orexin receptor type 2	0.0024	0.0132	0.0068
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.007	0.1421	0.1363
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Plasmodium falciparum	carbonic anhydrase	0.0063	0.1243	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0076	0.161	0.1736
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0132	0.0068
Brugia malayi	neuropeptide F receptor	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	ORL1-like opioid receptor	0.0024	0.0132	0.0066
Schistosoma mansoni	neuropeptide f receptor 76f	0.0024	0.0132	0.0073
Echinococcus multilocularis	glycogen phosphorylase	0.0229	0.5929	0.6085
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	growth hormone secretagogue receptor	0.0024	0.0132	0.0073
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Schistosoma mansoni	carbonic anhydrase-related	0.0063	0.1243	0.1323
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0024	0.0132	0.0068
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0125	0.2991	0.3287
Loa Loa (eye worm)	carbonic anhydrase 3	0.0206	0.5285	0.5253
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0206	0.5285	0.5253
Trypanosoma brucei	carbonic anhydrase-like protein	0.0206	0.5285	1
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0063	0.1243	0.1184
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.007	0.1421	0.1522
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.007	0.1421	0.1405
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0063	0.1243	0.1184
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.161	0.1602
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Toxoplasma gondii	hypothetical protein	0.0063	0.1243	1
Echinococcus granulosus	neuropeptide Y receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	hypothetical protein	0.0024	0.0132	0.0068
Schistosoma mansoni	neuropeptide F-like receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	serotonin receptor	0.0024	0.0132	0.0068
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0132	0.0073
Entamoeba histolytica	hypothetical protein	0.0035	0.0441	0.0342
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0024	0.0132	0.0068
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	carbonic anhydrase II	0.0206	0.5285	0.5416
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0041	0.0621	0.0743
Echinococcus granulosus	neuropeptides capa receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0024	0.0132	0.0068
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0076	0.161	0.1554
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0045	0.0716	0.2342
Echinococcus multilocularis	glycogen phosphorylase	0.0229	0.5929	0.6085
Schistosoma mansoni	hypothetical protein	0.0253	0.6599	0.7344
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.2991	0.3287
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0024	0.0132	0.0068
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0212	0.5452	1
Echinococcus multilocularis	g-protein coupled receptor	0.0024	0.0132	0.0068
Brugia malayi	Dopamine receptor	0.0024	0.0132	0.0066
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0063	0.1243	0.1184
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0132	0.0068
Echinococcus granulosus	neuropeptide FF receptor 2	0.0024	0.0132	0.0068
Trypanosoma brucei	unspecified product	0.0028	0.0246	0.0466
Echinococcus granulosus	allatostatin A receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	neuropeptide receptor A26	0.0362	0.9701	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0132	0.0073
Brugia malayi	putative neuropeptide receptor NPR1	0.0024	0.0132	0.0066
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	cathepsin b	0.0125	0.2991	0.3035
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	carbonic anhydrase II	0.0206	0.5285	0.5416
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0028	0.0246	0.018
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0045	0.0716	0.0674
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0132	0.0073
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0024	0.0132	0.0066
Echinococcus multilocularis	fmrfamide receptor	0.0024	0.0132	0.0068
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0045	0.0716	0.2342
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.007	0.1421	0.1405
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Loa Loa (eye worm)	G-protein coupled receptor	0.0024	0.0132	0.0066
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0024	0.0132	0.0068
Brugia malayi	G protein-coupled receptor F59B2.13	0.0024	0.0132	0.0066
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Schistosoma mansoni	amine GPCR	0.0024	0.0132	0.0073
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0024	0.0132	0.0073
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0041	0.0621	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	neuropeptide receptor	0.0024	0.0132	0.0068
Schistosoma mansoni	DNA polymerase eta	0.0028	0.0246	0.0201
Schistosoma mansoni	hypothetical protein	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Entamoeba histolytica	hypothetical protein	0.0035	0.0441	0.0342
Giardia lamblia	Cathepsin B precursor	0.0041	0.0621	0.0659
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.007	0.1421	0.1405
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0024	0.0132	0.0066
Echinococcus multilocularis	snurportin 1	0.0253	0.6599	0.678
Echinococcus granulosus	dna polymerase eta	0.0028	0.0246	0.0186
Brugia malayi	G protein-coupled receptor	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	somatostatin receptor	0.0024	0.0132	0.0068
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0024	0.0132	0.0073
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	sex peptide receptor	0.0024	0.0132	0.0068
Chlamydia trachomatis	glycogen phosphorylase	0.0229	0.5929	0.5
Brugia malayi	neuropeptide F receptor	0.0024	0.0132	0.0066
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0024	0.0132	0.0068
Echinococcus granulosus	importin subunit beta 1	0.0024	0.0123	0.0058
Echinococcus granulosus	cathepsin b	0.0125	0.2991	0.3035
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.0716	0.073
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0206	0.5285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0441	0.042
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0229	0.5929	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0024	0.0132	0.0066
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0063	0.1243	0.1184
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0272	0.714	0.7341
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.161	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0132	0.0068
Echinococcus granulosus	dro:myosuppressin receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1243	0.1184
Trypanosoma brucei	DNA polymerase IV, putative	0.0028	0.0246	0.0466
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0024	0.0132	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0024	0.0132	0.0066
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0229	0.5929	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0132	0.0066
Schistosoma mansoni	neuropeptide receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0246	0.018
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	cathepsin B	0.0041	0.0621	0.0557
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	snurportin 1	0.0253	0.6599	0.678
Brugia malayi	GnHR receptor homolog	0.0024	0.0132	0.0066
Brugia malayi	carbohydrate phosphorylase	0.0229	0.5929	0.5902
Echinococcus granulosus	g protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0045	0.0716	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Giardia lamblia	Cathepsin B precursor	0.0041	0.0621	0.0659
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0024	0.0132	0.0066
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0024	0.0132	0.0073
Echinococcus multilocularis	carbonic anhydrase	0.0063	0.1243	0.1221
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0229	0.5929	0.6085
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0206	0.5285	1
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0206	0.5285	0.5867
Echinococcus granulosus	neuropeptide s receptor	0.0362	0.9701	1
Brugia malayi	Dopamine receptor protein 1	0.0024	0.0132	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0028	0.0246	0.0186
Echinococcus multilocularis	neuropeptide s receptor	0.0362	0.9701	1
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0024	0.0132	0.0066
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0041	0.0621	0.0622
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0246	0.0466
Schistosoma mansoni	carbonic anhydrase-related	0.0063	0.1243	0.1323
Schistosoma mansoni	glycogen phosphorylase	0.0099	0.2253	0.2458
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Loa Loa (eye worm)	melatonin receptor type 1A	0.0024	0.0132	0.0066
Leishmania major	carbonic anhydrase-like protein	0.0206	0.5285	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0024	0.0132	0.0073
Schistosoma mansoni	amine GPCR	0.0024	0.0132	0.0073
Schistosoma mansoni	hypothetical protein	0.0063	0.1243	0.1323
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	G protein coupled receptor 139	0.0024	0.0132	0.0068
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0206	0.5285	0.5253
Schistosoma mansoni	opsin-like receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0024	0.0132	0.0066
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0028	0.0246	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus granulosus	carbonic anhydrase	0.0063	0.1243	0.1221
Brugia malayi	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	aldehyde dehydrogenase	0.0045	0.0716	0.073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	biogenic amine receptor	0.0024	0.0132	0.0073
Echinococcus granulosus	biogenic amine 5HT receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	neuropeptides capa receptor	0.0024	0.0132	0.0068
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Echinococcus granulosus	glycogen phosphorylase	0.0229	0.5929	0.6085
Echinococcus granulosus	rhodopsin orphan GPCR	0.0024	0.0132	0.0068
Brugia malayi	hypothetical protein	0.0035	0.0441	0.0376
Entamoeba histolytica	glycogen phosphorylase, putative	0.0229	0.5929	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0024	0.0132	0.0066
Loa Loa (eye worm)	neuropeptide F receptor	0.0024	0.0132	0.0066
Schistosoma mansoni	histamine h1 receptor	0.0024	0.0132	0.0073
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0024	0.0132	0.0068
Echinococcus granulosus	tm gpcr rhodopsin	0.0024	0.0132	0.0068
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0024	0.0132	0.0066
Schistosoma mansoni	amine GPCR	0.0024	0.0132	0.0073
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0063	0.1243	0.1184
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0028	0.0246	0.0186
Schistosoma mansoni	hypothetical protein	0.0035	0.0441	0.042
Echinococcus multilocularis	g protein coupled receptor	0.0024	0.0132	0.0068
Echinococcus multilocularis	allatostatin A receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	opsin-like receptor	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Schistosoma mansoni	hypothetical protein	0.0024	0.0132	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0024	0.0132	0.0068
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0125	0.2991	0.3287
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0024	0.0132	0.0068
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0229	0.5929	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0024	0.0132	0.0068
Brugia malayi	AKH receptor	0.0024	0.0132	0.0066
Toxoplasma gondii	cathepsin B	0.0041	0.0621	0.4443
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0123	0.0232
Echinococcus granulosus	cathepsin b	0.0125	0.2991	0.3035
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0024	0.0132	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0132	0.0066
Brugia malayi	putative neuropeptide receptor	0.0024	0.0132	0.0066
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.161	0.1602
Echinococcus granulosus	Glycosyl transferase family 35	0.0229	0.5929	0.6085
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0024	0.0132	0.0073
Schistosoma mansoni	carbonic anhydrase	0.0063	0.1243	0.1323
Trypanosoma brucei	importin beta-1 subunit, putative	0.0024	0.0123	0.0232

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1984625

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1650963