Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | histamine receptor H3 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.1864 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.1864 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 0.2423 | 0.2423 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1864 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1864 | 1 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.1864 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.1864 | 1 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.1864 | 1 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.011 | 0.0332 | 0.0332 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.0332 | 0.0332 |
Entamoeba histolytica | protein kinase, putative | 0.1864 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.2351 | 0.2351 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0489 | 0.2423 | 0.2423 |
Loa Loa (eye worm) | AUR protein kinase | 0.1864 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.011 | 0.0332 | 0.0332 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0158 | 0.0158 |
Brugia malayi | serine/threonine kinase 12 | 0.1864 | 1 | 1 |
Toxoplasma gondii | aurora kinase | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.011 | 0.0332 | 0.0332 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.1864 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.1864 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.1864 | 1 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.1864 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0707 | 0.362 | 0.362 |
Entamoeba histolytica | protein kinase , putative | 0.1864 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1864 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.011 | 0.0332 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.1864 | 1 | 0.5 |
Leishmania major | protein kinase, putative | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.011 | 0.0332 | 0.0332 |
Trypanosoma brucei | aurora B kinase | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.1864 | 1 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.1864 | 1 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.1864 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0707 | 0.362 | 0.362 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.1864 | 1 | 0.5 |
Giardia lamblia | Aurora kinase | 0.1864 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.1864 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11 nM | Displacement of [3H]-N-alpha-methylhistamine from human recombinant histamine H3 receptor after 30 mins by scintillation counting | ChEMBL. | 24900450 |
Ki (binding) | = 54 nM | Displacement of [3H]-N-alpha-methylhistamine from mouse recombinant histamine H3 receptor after 30 mins by scintillation counting | ChEMBL. | 24900450 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.