Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA topoisomerase ii | 0.0147 | 0.5616 | 1 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0018 | 0.0354 | 0.1735 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0155 | 0.5933 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0145 | 0.5516 | 1 |
Echinococcus granulosus | twitchin | 0.0012 | 0.0099 | 0.0487 |
Onchocerca volvulus | 0.0141 | 0.5382 | 0.9739 | |
Schistosoma mansoni | cell adhesion molecule | 0.0013 | 0.0127 | 0.0622 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0018 | 0.0354 | 0.1735 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.006 | 0.2039 | 0.3436 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.0226 | 0.1109 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0155 | 0.5933 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0255 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0255 | 1 | 1 |
Echinococcus multilocularis | neuroglian | 0.0012 | 0.0099 | 0.0487 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0255 | 1 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0013 | 0.0127 | 0.0622 |
Schistosoma mansoni | nephrin | 0.0012 | 0.0099 | 0.0487 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.006 | 0.2039 | 0.3436 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0041 | 0.1296 | 0.1791 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0255 | 1 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0255 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0041 | 0.1296 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0226 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1296 | 0.2185 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.006 | 0.2039 | 1 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0018 | 0.0354 | 0.1735 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.006 | 0.2039 | 0.3264 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.006 | 0.2039 | 0.3264 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.006 | 0.2039 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0018 | 0.0354 | 0.0596 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0041 | 0.1296 | 0.1791 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0018 | 0.0354 | 0.0596 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.006 | 0.2039 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0147 | 0.5616 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0018 | 0.0354 | 0.1735 |
Brugia malayi | DNA topoisomerase III | 0.0018 | 0.0354 | 0.0596 |
Leishmania major | DNA topoisomerase ii | 0.0041 | 0.1296 | 0.1791 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.006 | 0.2039 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0147 | 0.5616 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.006 | 0.2039 | 0.3436 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0018 | 0.0354 | 0.1735 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.006 | 0.2039 | 0.3436 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0127 | 0.0214 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.006 | 0.2039 | 0.3264 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1296 | 0.2185 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.006 | 0.2039 | 0.1747 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0018 | 0.0354 | 0.1735 |
Giardia lamblia | DNA topoisomerase II | 0.0052 | 0.1713 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0147 | 0.5616 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0226 | 0.0381 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0041 | 0.1296 | 0.1791 |
Echinococcus granulosus | neuroglian | 0.0012 | 0.0099 | 0.0487 |
Brugia malayi | GRF zinc finger family protein | 0.0018 | 0.0354 | 0.0596 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0088 | 0.3188 | 1 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.006 | 0.2039 | 0.3202 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0018 | 0.0354 | 0.0596 |
Schistosoma mansoni | DNA topoisomerase II | 0.006 | 0.2039 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0167 | 0.6423 | 0.6292 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0147 | 0.5616 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.006 | 0.2039 | 0.1747 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.0226 | 0.1109 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 40 uM | Cytotoxicity against human HL60 cells by MTT assay | ChEMBL. | 22548480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.