Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | anoctamin 1, calcium activated chloride channel | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Transmembrane protein 16G, putative | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Leishmania braziliensis | hypothetical protein, unknown function | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Schistosoma japonicum | Transmembrane protein 16C, putative | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Brugia malayi | Transmembrane protein 16C | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Onchocerca volvulus | Get druggable targets OG5_127202 | All targets in OG5_127202 | |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_127202 | All targets in OG5_127202 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.9922 | 0.9831 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0087 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0087 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0087 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 1 | 0.5 |
Echinococcus granulosus | dual specificity | 0.0087 | 1 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0087 | 1 | 0.5 |
Echinococcus multilocularis | dual specificity | 0.0087 | 1 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0087 | 1 | 1 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0087 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0087 | 1 | 0.5 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0087 | 1 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.9922 | 0.9831 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0087 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.5392 | 0.4752 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.9 uM | Inhibition of human TMEM16A transfected in FRT cells assessed as iodide influx using YFP-F46L/H148Q/I152L halide sensor after 10 mins by spectrofluorometric analysis | ChEMBL. | 22739085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.