Detailed view for Smp_083770

Basic information

TDR Targets ID: 286654
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 8.2812 | Length (AA): 712 | MW (Da): 83385 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04547   Calcium-activated chloride channel
PF16178   Dimerisation domain of Ca+-activated chloride-channel, anoctamin

Gene Ontology

Mouse over links to read term descriptions.
GO:0061588   GO:calcium activated phospholipid scrambling  

GO:0046983   protein dimerization activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 702 4wis (A) 60 654 23.00 0 1 0.878951 1.22
129 694 5oc9 (A) 186 635 34.00 0 1 0.874444 0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127202)

Species Accession Gene Product
Brugia malayi Bm1_23050   Transmembrane protein 16C
Caenorhabditis elegans CELE_F56A8.1   Protein ANOH-1, isoform A
Dictyostelium discoideum DDB_G0267752   hypothetical protein
Drosophila melanogaster Dmel_CG16718   CG16718 gene product from transcript CG16718-RA
Drosophila melanogaster Dmel_CG10353   CG10353 gene product from transcript CG10353-RF
Drosophila melanogaster Dmel_CG6938   CG6938 gene product from transcript CG6938-RB
Homo sapiens ENSG00000146205   anoctamin 7
Homo sapiens ENSG00000177119   anoctamin 6
Homo sapiens ENSG00000151572   anoctamin 4
Homo sapiens ENSG00000134343   anoctamin 3
Homo sapiens ENSG00000171714   anoctamin 5
Homo sapiens ENSG00000047617   anoctamin 2, calcium activated chloride channel
Homo sapiens ENSG00000131620   anoctamin 1, calcium activated chloride channel
Leishmania braziliensis LbrM.13.0560   hypothetical protein, unknown function
Loa Loa (eye worm) LOAG_03599   hypothetical protein
Mus musculus ENSMUSG00000074968   anoctamin 3
Mus musculus ENSMUSG00000031075   anoctamin 1, calcium activated chloride channel
Mus musculus ENSMUSG00000055489   anoctamin 5
Mus musculus ENSMUSG00000035189   anoctamin 4
Mus musculus ENSMUSG00000064210   anoctamin 6
Mus musculus ensembl-mmu:ENSMUSG00000034107   anoctamin 7
Mus musculus ENSMUSG00000038115   anoctamin 2
Onchocerca volvulus OVOC10884  
Schistosoma japonicum Sjp_0082990   Transmembrane protein 16G, putative
Schistosoma japonicum Sjp_0216380   Transmembrane protein 16C, putative
Schistosoma mansoni Smp_083770   hypothetical protein
Schmidtea mediterranea mk4.016970.01  
Schmidtea mediterranea mk4.012280.00   Anoctamin-7
Schmidtea mediterranea mk4.000078.15  
Schmidtea mediterranea mk4.016154.00  
Schmidtea mediterranea mk4.001069.04   Anoctamin-7
Schmidtea mediterranea mk4.012297.00   Anoctamin-7
Schmidtea mediterranea mk4.000078.16   Anoctamin-9
Schmidtea mediterranea mk4.000078.18  
Schmidtea mediterranea mk4.010647.00   Anoctamin-7
Schmidtea mediterranea mk4.000078.17  
Schmidtea mediterranea mk4.003056.03   Anoctamin-7
Schmidtea mediterranea mk4.003056.01   Anoctamin-7
Schmidtea mediterranea mk4.024512.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens anoctamin 1, calcium activated chloride channel Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1053 1 1
0.1068 0.4392 0.7691
0.0248 0.3047 0.7894
0.1053 1 1
0.1081 0.6391 0.7926
0.1042 1 1
0.1102 1 1
0.1112 0.4606 0.7961
0.1109 1 1
0.1081 0.6391 0.7926
0.1035 1 1
0.0827 0.3637 0.4901
0.1073 0.3333 0.7667
0.1081 0.6391 0.7926
0.1045 1 1
0.1127 0.691 0.7996
0.0644 0.9327 1
0.0598 0.3427 0.4146
0.0542 0.793 0.793
0.1155 0.4702 0.7825
0.1079 0.6669 0.7721
0.1099 0.9285 1
0.1082 1 1
0.0745 0.2709 0.2708
0.0827 0.7115 0.7457
0.0827 0.7115 0.7457
0.0181 1 1
0.0827 0.7115 0.7457
0.105 1 1
0.1072 0.6667 1
0.108 1 1
0.1049 1 1
0.1036 1 1
0.1089 1 1
0.1136 0.7855 0.8077
0.1133 1 1
0.1071 1 1
0.0786 0.2569 0.2569
0.1055 1 1
0.0786 0.2569 0.2569
0.105 1 1
0.1077 0.7407 0.7824
0.1123 1 1
0.1074 0.6569 0.7745
0.1068 0.4392 0.7691
0.0542 0.793 0.793
0.0061 0.5392 0.4752
0.1107 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_083770 (Schistosoma mansoni), hypothetical protein
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