Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fatty acid desaturase, putative | 0.3017 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2754 | 0 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.3017 | 1 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2754 | 0 | 0.5 |
Brugia malayi | acyl-CoA desaturase | 0.2754 | 0 | 0.5 |
Onchocerca volvulus | 0.3017 | 1 | 0.5 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2754 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.3017 | 1 | 0.5 |
Onchocerca volvulus | 0.3017 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.007 /s/microM | Inhibition of wild type HIV1 reverse transcriptase assessed as compound incorporation efficiency in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study | ChEMBL. | 22595174 |
K (binding) | = 0.16 /s | Binding affinity to wild type HIV1 reverse transcriptase assessed as compound incorporation in presence of 50 nM primer template and 10 mM MgCl2 by pre-steady state kinetics study | ChEMBL. | 22595174 |
Kd (binding) | = 22.4 uM | Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study | ChEMBL. | 22595174 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.