Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | acyl-CoA desaturase | 0.2729 | 0 | 0.5 |
Onchocerca volvulus | 0.2989 | 1 | 0.5 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2729 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2729 | 0 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.2989 | 1 | 0.5 |
Onchocerca volvulus | 0.2989 | 1 | 0.5 | |
Trypanosoma brucei | fatty acid desaturase, putative | 0.2989 | 1 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2729 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2989 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 27 % | Inhibition of [3H]serotonin uptake at human SERT expressed in CHO cells at 10 uM after 10 min by scintillation counting | ChEMBL. | 22608762 |
Inhibition (binding) | = 61 % | Inhibition of [3H]noradrenaline uptake at human NET expressed in CHO cells at 10 uM after 10 mins by scintillation counting | ChEMBL. | 22608762 |
Inhibition (binding) | = 64 % | Inhibition of [3H]dopamine uptake at human DAT expressed in CHO cells at 10 uM after 10 mins by scintillation counting | ChEMBL. | 22608762 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.