TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 470.569 | Formula: C26H30N8O
H donors: 2 H acceptors: 3 LogP: 3.85 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O1CCN(CC1)CCCNc1nc(N/N=C/c2nccn2Cc2ccccc2)nc2c1cccc2
InChi: 1S/C26H30N8O/c1-2-7-21(8-3-1)20-34-14-12-27-24(34)19-29-32-26-30-23-10-5-4-9-22(23)25(31-26)28-11-6-13-33-15-17-35-18-16-33/h1-5,7-10,12,14,19H,6,11,13,15-18,20H2,(H2,28,30,31,32)/b29-19+
InChiKey: DQEYXIUVJLJZQV-VUTHCHCSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	glucose transport protein	0.0102	0.2128	0.5158
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0081	0.1637	0.3944
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	0.1899
Leishmania major	glucose transporter, lmgt2	0.0032	0.0454	0.1018
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0023	0.024	0.0948
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0023	0.024	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0496
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0165	0.3622	0.3595
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.1018
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0184	0.4085	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0496
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1018
Onchocerca volvulus		0.0014	0.0042	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1018
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0023	0.024	0.0489
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0023	0.024	0.0489
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0444	0.0994
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0293	0.1375
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0199
Onchocerca volvulus		0.0014	0.0042	0.5
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0243	0.0201
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0398	0.088
Schistosoma mansoni	hypothetical protein	0.0102	0.2128	0.5158
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Loa Loa (eye worm)	sugar transporter	0.0102	0.2128	1
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.1018
Onchocerca volvulus		0.0014	0.0042	0.5
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0165	0.3622	0.5495
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0184	0.4085	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0444	0.1927
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.0957
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0059	0.1098	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0496
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0445	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0243	0.1899
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0454	0.1018
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0113	0.0174
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.024	0.0489
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.055	0.051
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1018
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0243	0.0496
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0243	0.1141
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Onchocerca volvulus		0.0014	0.0042	0.5
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0454	0.1018
Loa Loa (eye worm)	sugar transporter	0.0014	0.0042	0.0199
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Plasmodium falciparum	phosphodiesterase delta, putative	0.0023	0.024	0.0199
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3546	0.8667
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1855
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0023	0.024	0.0489
Schistosoma mansoni	protein kinase	0.0031	0.0444	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Onchocerca volvulus		0.0014	0.0042	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0445	0.0617
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0199
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0059	0.1098	1
Mycobacterium ulcerans	putative regulatory protein	0.0059	0.1098	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0023	0.024	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0023	0.024	0.1128
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0444	0.0994
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0444	0.2088
Onchocerca volvulus		0.0014	0.0042	0.5
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0444	0.2088
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0496
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Schistosoma mansoni	glucose transport protein	0.0102	0.2128	0.5158
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0243	0.0496
Toxoplasma gondii	hypothetical protein	0.0162	0.3546	0.5378
Plasmodium falciparum	protein kinase 7	0.0288	0.6557	0.6542
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3546	0.8667
Plasmodium falciparum	hexose transporter	0.0102	0.2128	0.2094
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0243	0.5
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0023	0.024	0.1128
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0165	0.3622	0.3595
Onchocerca volvulus		0.0014	0.0042	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0023	0.024	0.0489
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Giardia lamblia	Hypothetical protein	0.0023	0.024	0.5111
Leishmania major	protein kinase, putative	0.0031	0.0444	0.0994
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0454	0.1018
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0161	0.1126
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0081	0.1637	0.7645
Loa Loa (eye worm)	PDE1B protein	0.0023	0.024	0.1128
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0444	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0184	0.4085	1
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1637	0.7692
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0023	0.024	0.0489
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0445	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	0.1255
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0023	0.024	0.5111
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0023	0.024	0.0199
Echinococcus multilocularis	General substrate transporter	0.0088	0.1787	0.4314
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.0957
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0184	0.4085	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.9253
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.024	0.0489
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0243	0.0308
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0454	0.1018
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0445	0.0404
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0125	0.2688	0.6545
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Onchocerca volvulus		0.0014	0.0042	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0243	0.0872
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0042	0.5
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3546	0.8667
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0023	0.024	0.0489
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0398	0.088
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0454	0.1018
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0081	0.1637	0.3944
Leishmania major	glucose transporter, lmgt3	0.0032	0.0454	0.1018
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Plasmodium vivax	hexose transporter	0.0102	0.2128	0.2094
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	0.1255
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	0.1255
Mycobacterium ulcerans	putative regulatory protein	0.0059	0.1098	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1098	0.5159
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Echinococcus granulosus	General substrate transporter	0.0088	0.1787	0.4314
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0023	0.024	0.0489
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0199
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0161	0.1126
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0199
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0023	0.024	0.0489
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0433	1	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0445	0.0404
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0102	0.2128	0.3201
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	conserved hypothetical protein	0.0184	0.4085	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0243	0.5182
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0454	0.1018
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0199
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0023	0.024	0.0489
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0445	0.0617
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0445	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0023	0.024	0.1128
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0184	0.4085	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0429	0.0957
Brugia malayi	Cam kinase protein 1	0.0031	0.0444	0.1927
Onchocerca volvulus		0.0014	0.0042	0.5
Onchocerca volvulus		0.0014	0.0042	0.5
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0081	0.1637	0.3944
Toxoplasma gondii	GAF domain-containing protein	0.0059	0.1098	0.162
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.055	0.0779
Giardia lamblia	hypothetical protein	0.0023	0.024	0.5111
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0102	0.2128	0.5158
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0023	0.024	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Plasmodium vivax	phosphodiesterase gamma, putative	0.0023	0.024	0.0199
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0023	0.024	0.0489
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.055	0.1255
Trypanosoma cruzi	hexose transporter	0.0032	0.0454	0.1018
Toxoplasma gondii	hypothetical protein	0.0059	0.1098	0.162
Plasmodium vivax	hypothetical protein, conserved	0.0059	0.1098	0.106
Onchocerca volvulus		0.0014	0.0042	0.5
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0243	0.0961
Schistosoma mansoni	protein kinase	0.0031	0.0444	0.0994
Toxoplasma gondii	hypothetical protein	0.0059	0.1098	0.162
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0023	0.024	0.0489
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0059	0.1098	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.024	0.0489
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Onchocerca volvulus		0.0014	0.0042	0.5
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0125	0.2688	0.6545
Schistosoma mansoni	protein kinase	0.0031	0.0444	0.0994
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0102	0.2128	0.5158
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.2128	0.5158
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0023	0.024	0.0489
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0429	0.0957
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0023	0.024	0.0489
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0176	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0023	0.024	0.0199
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.1018
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0243	0.0201
Entamoeba histolytica	protein kinase, putative	0.0031	0.0444	1
Onchocerca volvulus		0.0014	0.0042	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0454	0.1018
Mycobacterium leprae	conserved hypothetical protein	0.0059	0.1098	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0454	0.1018
Brugia malayi	Sugar transporter family protein	0.0102	0.2128	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0429	0.1855
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0023	0.024	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0023	0.024	0.1128
Onchocerca volvulus		0.0014	0.0042	0.5
Leishmania major	glucose transporter, lmgt1	0.0032	0.0454	0.1018
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0023	0.024	0.0489
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0445	0.0404
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0444	0.0994
Onchocerca volvulus	Putative transporter	0.0014	0.0042	0.5
Leishmania major	hypothetical protein, conserved	0.0023	0.024	0.0489
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0444	0.2088
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0184	0.4085	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Onchocerca volvulus		0.0014	0.0042	0.5
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0184	0.4085	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0081	0.1637	0.7645
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.055	0.051
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0023	0.024	0.0489
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0184	0.4085	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0429	0.0957
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0445	0.0617
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0184	0.4085	1
Entamoeba histolytica	protein kinase, putative	0.0031	0.0444	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0023	0.024	0.0489
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0023	0.024	0.0948
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Toxoplasma gondii	protein kinase, putative	0.0288	0.6557	1
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.1098	0.2611
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0042	0.0199
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0081	0.1637	0.3944
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0445	0.0404
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0081	0.1637	0.3944
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0429	0.2861
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0023	0.024	0.0489
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0243	0.0496
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0125	0.2688	0.6545
Plasmodium falciparum	GAF domain-related protein, putative	0.0059	0.1098	0.106
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0184	0.4085	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0444	0.0994
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0243	0.0496
Leishmania major	hypothetical protein, conserved	0.0023	0.024	0.0489
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0081	0.1637	0.3944
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0454	0.1018
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0429	1
Onchocerca volvulus		0.0014	0.0042	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0429	0.2017
Schistosoma mansoni	glucose transport protein	0.0102	0.2128	0.5158
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0184	0.4085	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0445	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0445	0.0404
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0023	0.024	0.0489
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0023	0.024	0.0303
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.024	0.0489
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0184	0.4085	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.055	0.1255

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4.03 umol/L	Cytotoxicity against human H460 cells after 72 hrs by MTT assay	ChEMBL.	22727449

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	22727449

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2042934

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1653476